NeuroscienceMolecular NeurodegenerationPeer-reviewed
The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic Neurons
Yuanxin Chen, Lianteng Zhi, Shiquan Cui…·Hui Zhang
This study shows that the LRRK2-R1441G mutation causes age-related mitochondrial dysfunction and oxidative stress in dopamine neurons, suggesting calcium channels and uncoupling proteins as therapeutic targets.