Author

Sylvain Le Gludic

University of GenevaORCID 0009-0002-9296-2671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Andrea AlimontiiD· 2 shared Aurélien ThomasiD· 2 shared Cristina MenniiD· 2 shared Florentin ConstanciasiD· 2 shared Francesco PaneniiD· 2 shared Frank RuschitzkaiD· 2 shared Khatereh Shabanian· 2 shared Manuel ColucciiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Andrea AlimontiORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 2, 2026

Gut Microbiota Production of Phenylacetate Programs Vascular Niche Senescence and Drives Atherosclerosis

Khatereh Shabanian, Florentin Constancias, BenoÃ®t Pugin…·Seyed Soheil Saeedi Saravi

This study identifies phenylacetate (PAA), a gut microbiota metabolite, as a driver of vascular niche senescence and atherosclerosis in mice through IL-6-Notch1 signaling.

DOI 10.64898/2026.02.27.708541

mousehuman

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Cell BiologybioRxivNov 17, 2023

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

Seyed Soheil Saeedi Saravi, Benoit Pugin, Florentin Constancias…·Jürg H. Beer

This study shows that gut microbiota-dependent phenylacetic acid (PAA) increases endothelial cell senescence and impairs angiogenesis in aging, with acetate able to reverse these effects.

DOI 10.1038/s43587-025-00864-8

humanmouse

𝕏 PostBluesky