Chen Liu

This study identifies the conserved NUS-1/DHDDS complex in C. elegans as essential for linking N-glycosylation to lipid and lysosomal homeostasis, revealing its role in preventing developmental failure and metabolic disorders.

The paper identifies hedgehog APN as a receptor for EriCoVs and shows convergent evolution in its utilization among merbecoviruses.

The paper shows that HKU25 clade MERS-related coronaviruses use ACE2 as a receptor, challenging prior beliefs that DPP4 was their main receptor.

HKU5 merbecoviruses use bat Pipistrellus abramus ACE2 and several artiodactyl ACE2s through a cryo-EM-defined binding mode distinct from other ACE2-using coronaviruses, showing independent evolution of ACE2 usage.

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

This paper introduces a DNA data storage scheme using 5-methylcytosine to increase information density, achieving high data recovery rates in experimental validation.

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

This paper introduces a protein microarray-based in vitro transglutaminase assay platform to identify TG modification sites and their implications for immunodominant epitope determination.

This paper develops an automated 3D inner ear modeling method to assess morphological similarities across species, finding mini pigs closely resemble humans in key structures.

SEQdata-BEACON collects and analyzes BGISEQ-500 sequencing performance data to simulate yield and improve sequencing process understanding.