Smruti Ranjan Rout

This study investigates how the p97/VCP mutation D395G increases redox sensitivity, leading to oxidative inactivation and contributing to neurodegeneration.

This study shows that SARS-CoV-2's ORF3a protein induces lysosomal membrane atg8ylation, which protects cells from death by limiting ORF3a-induced cell death.

This study uses cryo-EM, NMR, and MD simulations to reveal the atomic-level mechanism of ATP processing by p97, identifying a metastable ADP.Pi state and its role in coordinating subunit actions.