Xin-Yang Wei

This study identifies DRT4 as a dual-sensor immune system that uses phage-derived signals to activate an RNA-targeting reverse transcriptase for anti-phage defense.

This study shows DRT7, a reverse transcriptase-primase, generates protein-templated DNA to provide broad-spectrum antiviral immunity through abortive infection.

This study reveals the molecular mechanism of Retron-Eco8 immunity by determining cryo-EM structures of the system in inactive and activated states, showing how phage SSB triggers nuclease activation and cell death.

The paper determines the structure of the SPARTA immune system, revealing how it activates NADase activity in response to ssDNA targets.