Author
Cancer Research UK Scotland InstituteORCID 0009-0003-5246-3955Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Declan Whyte, Sophie L Fisher, Christopher G J McKenzie…·Cassie J. Clarke
Michalis Gounis, America V. Campos, Engy Shokry…·Cassie J. Clarke
The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.
Joseph A. Waldron, Georgios Kanellos, Rachael C.L. Smith…·Owen James Sansom
This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.
Madeleine Moore, Luis Pardo, Louise E. Mitchell…·Jim C. Norman
The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.