Author

Madeleine Gapp

Max-von-Pettenkofer-Institut für Hygiene und Medizinische MikrobiologieORCID 0009-0004-5427-184XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Oliver Till KeppleriD· 2 shared Adrian RuhleiD· 1 shared Gerhard DyckhoffiD· 1 shared Hong‐Ru CheniD· 1 shared Hsiu-Hui YangiD· 1 shared Javier M. VillamizariD· 1 shared Katharina Morath· 1 shared Lopamudra Sadhu· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

Oliver Till KepplerORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintAug 5, 2026

Optimizing CRISPR/Cas9 genome editing in primary human hematopoietic cells to advance studies into HIV biology

Hong‐Ru Chen, Nicole P. Kadzioch, Madeleine Gapp…·Manuel Albanese

This study develops a CRISPR/Cas9 platform for editing primary human HSPCs to investigate HIV host factors and their impact on viral infection in vitro and in vivo.

DOI 10.64898/2026.08.05.741689

humangenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologyCell Reports MethodsPeer-reviewedJan 1, 2024

ediTONSIL: Activation-Neutral Gene Editing of CD4 T cells in Human ex Vivo Tonsil Cultures

Katharina Morath, Lopamudra Sadhu, Gerhard Dyckhoff…·O. T. Fackler

The paper introduces ediTONSIL, a method to edit resting CD4 T cells from human tonsil tissue without activation, achieving >90% knockout efficacy and preserving cell function.

9 citations

humanCITE-seq

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