Author

Karen Nguyen

Howard Hughes Medical InstituteORCID 0009-0004-7898-1969Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:protein structure· 1

Frequent Co-Authors

Daniel R. ZollingeriD· 2 shared Jill McKay-Fleisch· 2 shared Yan LiangiD· 2 shared Alan J. EmanueliD· 1 shared Alecksandr J. Kutchma· 1 shared Alexa E Lasley· 1 shared Alia M. ObeidatiD· 1 shared Andrew Klock· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Daniel R. ZollingerORCID

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3 papers

Recent·Most cited

NeuroscienceNeuronPeer-reviewedJul 1, 2026

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses

Karina Lezgiyeva, Jingyi Liu, Karen Nguyen…·David D. Ginty

The paper identifies A{delta}-HTMRs as fast-conducting mechanonociceptors that drive protective pain responses through unique spinal reflex circuits.

7 citationstop 1%

mouseexperimental assay

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GenomicsbioRxivPreprintSep 29, 2021

Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial Profiling

Stephanie M. Zimmerman, Robin Fropf, Bridget R. Kulasekara…·Joseph Beechem

Multiplexed in situ hybridization pools against every protein-coding gene let Digital Spatial Profiling read whole transcriptomes from regions of ~10-500 cells in human and mouse tissue.

60 citations

𝕏 PostBluesky

PathologybioRxivPreprintFeb 26, 2019

High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methods

Christopher R. Merritt, Giang T. Ong, Sarah Church…·Joseph M. Beechem

This paper introduces Digital Spatial Profiling (DSP), a method for high-plex spatial analysis of proteins and RNA in tissue, and demonstrates its application in studying immune and cancer microenvironments.

DOI 10.1101/559021

humanprotein structure

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