ImmunologyComputational and Structural Biotechnology JournalPeer-reviewed
Directed disruption of IL2 aggregation sites produces designer biologics with enhanced specificity coupled to improved production capacity
A. J. Dashwood, Ntombizodwa Makuyana, Rob van der Kant…·Adrian Liston
This paper designs IL2 muteins with enhanced Treg or CD8 T cell specificity and improved production by predicting mutations using SolubiS and testing their functional and structural properties.