Fenglei Li

This study shows that T cell ectosomes, containing TCRs, enhance B cell antibody production by engaging cognate pMHCII, providing a new mechanism of T cell help.

This study identifies ligand-induced segregation of phosphatases CD45 and CD148 from {gamma}{delta} TCRs as essential for TCR triggering by nonclassical MHC class Ib antigens.

This study shows that varying CAR-antigen complex span affects CAR-T cell activation and effector responses, with optimal activation occurring at a span matching TCR-pMHC complexes.