P. Anton van der Merwe

This study develops a model explaining how nanometre-scale changes in receptor dimensions affect CAR-T cell antigen sensitivity by linking physical principles to experimental observations.

This study shows that switching CD8 with CD4 co-receptor in cytotoxic T cells reduces off-target cross-reactivity without altering the TCR, enhancing T cell therapy safety.

This paper measures 3D affinities of the OT-I TCR to 19 pMHC complexes and finds they strongly correlate with 2D membrane affinities, revealing imperfect antigen discrimination.

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

This study compares cytokine production kinetics in TCR-T cells and CAR-T cells with and without co-stimulation, finding that 2nd-generation CAR-T cells sustain cytokine production without co-stimulation.

The paper investigates how ACE2 missense variants affect SARS-CoV-2 Spike binding, identifying variants that enhance or inhibit binding and their potential impact on infection risk.