Atul Pranay

This study investigates the role of PFKFB2 in cardiac metabolic flexibility and glucose utilization, finding that its loss impairs mitochondrial function and affects systemic glucose homeostasis under stress.

The paper identifies and validates a new inhibitor, B2, of PFKFB2 kinase activity through enzymatic assays and metabolic profiling in A-498 cells.

This study shows that loss of cardiac PFKFB2 leads to metabolic, functional, and electrophysiological changes in the heart, including impaired systolic function and altered electrophysiology.