Kylene M. Harold

This paper shows that loss of PFKFB2 in cardiac cells leads to electrophysiological instability, including prolonged repolarization and ventricular tachyarrhythmia, linking glycolytic regulation to heart function.

This study investigates the role of PFKFB2 in cardiac metabolic flexibility and glucose utilization, finding that its loss impairs mitochondrial function and affects systemic glucose homeostasis under stress.

The paper investigates synaptic input changes in VTA dopamine neurons of 3xTg-AD mice, finding enhanced excitatory input and reduced inhibition linked to PKC activity.

This study shows that loss of cardiac PFKFB2 leads to metabolic, functional, and electrophysiological changes in the heart, including impaired systolic function and altered electrophysiology.