Andrea Salati

CoPhaser models biological cycles in scRNA-seq by decomposing data into periodic and non-periodic sources, revealing insights into cell cycle dynamics and other periodic processes across diverse contexts.

This paper introduces scRitmo, a method to infer circadian phases and quantify biological desynchrony from single-cell transcriptomes, showing improved performance over existing methods.

The paper identifies a sexually dimorphic hepatic cycle of VLDL generation and re-uptake in mice and humans, linking VLDLR expression to cardiovascular risk.