Author

Kathy McLay

University of GlasgowORCID 0009-0006-9764-3839Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Joanna L. BirchiD· 2 shared AJ Chalmers· 1 shared Andrew D. CampbelliD· 1 shared Arafath Kaja NajumudeeniD· 1 shared Catriona A. FordiD· 1 shared Colin NixoniD· 1 shared Crispin J. MilleriD· 1 shared Dale M. WattiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Joanna L. BirchORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 9, 2025

Radiotherapy drives lung metastasis in PDAC via a RhoGTPasesignaling shift towards MRCK-dependency

Kathy McLay, Mathias Tesson, Louise R. Dutton…·JL Birch

This study shows that radiotherapy promotes lung metastasis in PDAC by increasing MRCK activity, which can be inhibited by BDP9066.

DOI 10.1101/2025.09.09.673965

mousebulk RNA-seq

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Cancer BiologyCancer ResearchPeer-reviewedOct 16, 2024

Kras loss of heterozygosity promotes MAPK dependent pancreatic ductal adenocarcinoma and induces therapeutic sensitivity

Sigrid K. Fey, Arafath Kaja Najumudeen, Dale M. Watt…·Owen James Sansom

This study shows that loss of wild-type Kras enhances oncogenic Kras signaling and promotes pancreatic ductal adenocarcinoma, while also increasing sensitivity to MEK1/2 inhibitors.

12 citations

mouseexperimental assay

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