Amilia Meir

This study shows that sustained exposure of human HSPCs to CAR-T cell secretome impairs their function, but this effect is reversible with dual TNFα-IFNγ blockade.

The paper investigates CAR T-cell dysfunction in the CNS, identifying BBB-induced activation-induced cell death as a mechanism of resistance.

This study shows that galactose-based media improves mitochondrial function and efficacy of CAR-T cells, leading to better leukemia-free survival in mice.