Elad Jacoby

This paper describes the engineering of a bispecific fusion protein combining CTLA-4 and IL-10 to modulate immune checkpoints and cytokine receptors, showing T cell-inhibitory effects in vitro.

This study shows that sustained exposure of human HSPCs to CAR-T cell secretome impairs their function, but this effect is reversible with dual TNFα-IFNγ blockade.

The paper investigates CAR T-cell dysfunction in the CNS, identifying BBB-induced activation-induced cell death as a mechanism of resistance.

This study shows that galactose-based media improves mitochondrial function and efficacy of CAR-T cells, leading to better leukemia-free survival in mice.