Author

George Cairns

University of OttawaORCID 0009-0007-6303-6317Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jeremy RacineiD· 2 shared Madhavee Thumiah-Mootoo· 2 shared Mah Rukh Abbasi· 2 shared Melissa GourlayiD· 2 shared Mireille KhachoiD· 2 shared Nikita Larionov· 2 shared Yan BurelleiD· 2 shared Alexandre BlaisiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCell Biology

Jeremy RacineORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 23, 2026

LOSS OF PARKIN DISRUPTS NUCLEAR AND MITOCHONDRIAL PROGRAMS REQUIRED FOR MUSCLE REGENERATION

Melissa Gourlay, Mah Rukh Abbasi, George Cairns…·Yan Burelle

This study shows PARKIN is essential for coordinating mitochondrial and nuclear processes in muscle stem cells during regeneration, with loss of PARKIN causing metabolic and RNA processing defects.

DOI 10.64898/2026.03.20.712989

mousebulk RNA-seq

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Cell BiologybioRxivJun 23, 2023

PINK1 Deficiency Alters Muscle Stem Cell Fate Decision And Muscle Regenerative Capacity.

George Cairns, Madhavee Thumiah-Mootoo, Mah Rukh Abbasi…·Yan Burelle

This study shows that PINK1 deficiency impairs muscle stem cell mitophagy, leading to mitochondrial dysfunction and reduced muscle regeneration.

DOI 10.1016/j.stemcr.2024.03.004

mouseproteomics

𝕏 PostBluesky