Tommy K. Cheung

The paper develops nanoMAPS, a droplet-based magnetic affinity purification system for surfaceome profiling of 100-500 cells, improving recovery and reducing non-specific absorption.

The paper determines the cryo-EM structure of the holocentric CCAN from Bombyx mori, revealing a self-contained dimer that forms a point-centromere-like architecture and incorporates novel Centromeric Subunit proteins.

This study identifies phosphorylated ubiquitin (pS65Ub) as a signaling molecule that mediates mitochondrial-to-nuclear communication by modulating histone ubiquitination and gene expression in Parkinson's disease.

The paper introduces toma-scpMS, a method that improves quantification in multiplexed single cell proteomics by separating carrier and single cell proteomes during mass spectrometry.

This paper identifies a potent and specific SMARCA2/A4 degrader, G-6599, which works via FBXO22 recruitment and covalent conjugation, offering therapeutic potential.

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.