Olga Sirbu

The paper analyzes RNA-Seq data of CLL cells to identify toggle genes and temporal differentially expressed genes, showing their role in cell-state transitions and population plasticity.

The paper reanalyzes lifespan studies and finds that short-lived controls overestimate intervention efficacy, proposing a 900-day rule to assess confidence in longevity interventions.

The paper shows that aging and senescence increase transposon expression through transcriptional readthrough and intron retention, not autonomous transposon activity.