Zhen-Dong Zhong

OpenBase provides a framework for high-accuracy detection of diverse non-canonical DNA bases using nanopore sequencing through standardized training data and deep learning models.

This study uses nanopore direct RNA sequencing to analyze how m6A modifications and poly(A) tail dynamics influence RNA degradation kinetics and isoform-specific decay.

This study introduces SingleMod, a deep learning model for m6A modification mapping using single-molecule RNA sequencing, revealing m6A heterogeneity and species-specific distribution patterns.