Guan‐Zheng Luo

OpenBase provides a framework for high-accuracy detection of diverse non-canonical DNA bases using nanopore sequencing through standardized training data and deep learning models.

This study uses nanopore direct RNA sequencing to analyze how m6A modifications and poly(A) tail dynamics influence RNA degradation kinetics and isoform-specific decay.

This study introduces SingleMod, a deep learning model for m6A modification mapping using single-molecule RNA sequencing, revealing m6A heterogeneity and species-specific distribution patterns.

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

The paper identifies and characterizes m6A sites across human and mouse cell lines and tissues, revealing distinct features of high and low consistency m6A sites and their associations with gene regulation.

This paper introduces an antibody-independent method for single-base m6A mapping, showing high reliability and conservation across species.