Sebastian Lindner

This paper introduces REXzyme, a model translating chemical reactions into enzyme sequences, and demonstrates its ability to generate active formate dehydrogenases for CO2 reduction.

The paper identifies that air bubbles in water bottles can cause dehydration in mice, and proposes a coiled wire solution to prevent this.

The paper maps the sequence-to-function relationship of rubisco by assaying single amino acid mutants in E. coli, identifying conserved positions and mutations that improve CO2 affinity.

An enzyme-specific conditional language model generates active carbonic anhydrases and lactate dehydrogenases to user specification, some under 40% identity to natural proteins, with no retraining.