The percentage of Monocytes CD39+ is higher in Pregnant COVID-19 than in Non-Pregnant COVID-19 patients
A. Cerbulo-Vazquez, M. Garcia-Espinosa, J. C. Briones-Garduno, L. A. Arriaga-Pizano, E. Ferat-Osorio, B. Zavala-Barrios, G. L. Cabrera-Rivera, P. Miranda-Cruz, M. T. Garcia de la Rosa, J. L. Prieto-Chavez, V. Rivero-Arredondo, R. L. Madera-Sandoval, A. Cruz-Cruz, E. Salazar-Rios, M. E. Salazar-Rios, D. Serrano-Molina, R. C. De Lira-Barraza, A. H. Villanueva-Compean, A. Esquivel-Pineda, R. Ramirez-Montes de Oca, F. Caldino-Soto, L. A. Ramirez-Garcia, M. G. Flores-Padilla, O. Moreno-Alvarez, G. M. L. Guerrero-Avendano, C. Lopez-Macias
Abstract
Current medical guidelines consider COVID-19 pregnant women a high-risk group. Physiological gestation down regulates the immunological response to maintain "maternal-fetal tolerance"; hence, a SARS-CoV-2 infection constitutes a potentially threatening condition to both the mother and the fetus. To establish the immune profile in pregnant COVID-19+ patients a cross-sectional study was conducted. Leukocyte immunophenotype, mononuclear leukocyte response to polyclonal stimulus and cytokine/chemokine serum concentration were analyzed in pregnant fifteen COVID-19+ and control groups (fifteen non-pregnant COVID-19+, and thirteen pregnant COVID-19-women). Pregnant COVID-19+ patients exhibit lower percentages of monocytes HLA-DR+ compared with control groups. Nevertheless, pregnant COVID-19+ women show a higher percentage of monocytes CD39+ than controls. Furthermore, a higher concentration of TNF-, IL-6, MIP1b and IL-4 was observed within the pregnant COVID-19+ group. Our result shows that pregnant women express immunological characteristics that potentially mediate the immune response in COVID-19.
02 /Specification & Classification
Click any tag to browse matching papers- Organism
- Assay
- Research Focus
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Decidual immune response following COVID-19 during pregnancy varies by timing of maternal SARS-CoV-2 infection
L. J. Juttukonda, E. M. Wachman, … E. S. Taglauer·bioRxiv·Nov 20, 2021
- Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cells in recovered COVID-19 pregnant women
N. H. A. Aziz, M. S. Salker, … Y. Singh·bioRxiv·Aug 18, 2022
- Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection
S. Sureshchandra, M. Z. Zulu, … I. Messaoudi·bioRxiv·Aug 23, 2021
- Maternal cytokine response after SARS-CoV-2 infection during pregnancy
F. A. J. Gigase, N. M. Molenaar, … L. D. De Witte·bioRxiv·Jan 4, 2022
- COVID-19 mRNA vaccines drive differential Fc-functional profiles in pregnant, lactating, and non-pregnant women
C. Atyeo, E. A. Deriso, … G. J. Alter·Science Translational MedicinePeer-reviewed·Oct 27, 2021
- The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate
S. Gee, M. Chandiramani, … D. L. Gibbons·bioRxiv·May 27, 2021