Nanomotion technology for testing azithromycin susceptibility of Salmonella enterica
Mariliis HinnuiD, Toomas MetsiD, Ivana Kerkez, Marta PutrinšiD, Niilo KaldaluiD, Gino CathomeniD, Marta Pla VergeiD, Danuta CichockaiD, Alexander SturmiD, Tanel TensoniD, Christèle Aubry, Amanda Luraschi, Maria Georgevia, Gilbert GreubiD, María García-CastilloiD, Rafael CantóniD, Nicolas Oswaldo Trinler, Susanne HäußleriD, Tailise de Souza Guerreiro Rodrigues, Stefano PagliaraiD
Abstract
Azithromycin is used to treat invasive salmonellosis, despite conflicting effective concentrations in vitro and in vivo. Resistance of Salmonella enterica to azithromycin is increasing. We demonstrate that nanomotion technology can be used for rapid phenotypic testing of Salmonellas susceptibility to azithromycin. Nanomotion changes under various culture conditions correlated with susceptibility measured by MIC determination, CFU counting, and fluorescent reporter-based estimates of intrabacterial azithromycin accumulation.
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