Targeting Macrophage Folate Receptor-β for Diagnosis and Treatment of Autoimmune Myocarditis
Arghavan Jahandideh, Erika Atencio HerreiD, Wail NammasiD, Jenni VirtaiD, Heidi LiljenbäckiD, Jesse Ponkamo, Andriana Putri, Xiaoqing ZhuangiD, Johan RajanderiD, Madduri SrinivasaraoiD, Philip Stewart LowiD, Yingjuan June Lu, Xiang‐Guo LiiD, Juhani M. KnuutiiD, Anne RoivaineniD, Antti SarasteiD
Abstract
We investigated folate receptor-{beta} (FR-{beta}) expressed on activated macrophages as a therapeutic and imaging target in autoimmune myocarditis (AIM). Treatment with a folate-aminopterin conjugate (EC2319) targeting FR-{beta}-positive macrophages significantly reduced macrophage infiltration compared to saline (5.23 {+/-} 2.84% vs. 1.24 {+/-} 0.66%, P View larger version (36K): org.highwire.dtl.DTLVardef@18e9296org.highwire.dtl.DTLVardef@139b8b3org.highwire.dtl.DTLVardef@8d1a74org.highwire.dtl.DTLVardef@1c3f06d_HPS_FORMAT_FIGEXP M_FIG C_FIG
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