K. Lavine

Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T

This study connects genotype, phenotype, and drug response in dilated cardiomyopathy using molecular mechanism-based computational and experimental approaches for a troponin T mutation.

CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2+ macrophages and CD8 T-cells

This study shows CD40 agonists promote myocardial inflammation by activating CCR2+ macrophages and CD8 T-cells, leading to heart failure.

Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility

This study shows that the ACTA1 R256H mutation disrupts actin structure and function in cardiomyocytes, leading to reduced contractility and a likely causative role in dilated cardiomyopathy.

Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy

This study shows that inhibiting soluble epoxide hydrolase reduces inflammation and myocardial injury in arrhythmogenic cardiomyopathy by increasing pro-resolving lipid mediators.

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

Mechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy

This study identifies NFκB signaling in cardiac myocytes as a driver of myocardial injury and arrhythmias in a mouse model of arrhythmogenic cardiomyopathy.

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

Donor Macrophages Modulate Rejection after Heart Transplantation

This study identifies donor CCR2+ macrophages as key drivers of heart transplant rejection and shows that inhibiting MYD88 signaling in these cells extends graft survival.

Circulating osteopontin released by injured kidneys causes pulmonary inflammation and edema

This study identifies osteopontin (OPN) released by injured kidneys as a mediator of acute lung injury, showing its role in causing pulmonary inflammation and edema.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.