Metastatic potentials classified with hypoxia-inducible factor 1 downstream gene in pan-cancer cell lines

Abstract

Hypoxia-inducible factor 1 (HIF1) gene codes a transcription factor that is stabilized under hypoxia conditions via post-translational modifications. HIF1 regulates tumor malignancy and metastasis by gene transcriptions, such as Warburg effect- and angiogenesis-related genes, in cancer cells. However, the HIF1 downstream genes show varied expressional patterns in different cancer types. Herein, we performed the hierarchical clustering based on the HIF1 downstream gene expression patterns using 1,406 cancer cell lines crossing 30 types of cancer to understand the relationship between HIF1 downstream genes and the metastatic potential of cancer cell lines. Four types of cancer were classified by HIF1 downstream genes with significantly altered metastatic potentials. Furthermore, different HIF1 downstream gene subsets were extracted to discriminate each subtype for the four cancer types. HIF1 downstream subtyping classification will help understand the novel insight into tumor malignancy and metastasis in each cancer type. FundingThis work was supported by Project for JSPS KAKENHI (Grant-in-Aid for Scientific Research (C): JP23K06665 to JN, Grant-in-Aid for Early-Carrier Scientists: JP21K15562 to JN), and in part by translational research program from Fukushima Prefecture (KS). Competing Interests statementThe authors have declared that no conflict of interest exists.