K. Semba

Metastatic potentials classified with hypoxia-inducible factor 1 downstream gene in pan-cancer cell lines

The paper classifies metastatic potentials in cancer cell lines using HIF1 downstream gene expression patterns across 30 cancer types.

Targeting c-Jun is a potential therapy of luminal breast cancer bone metastasis

This study identifies c-Jun as a novel marker for luminal breast cancer bone metastasis and shows its inhibition reduces metastatic potential.

Prediction of Resistant Mutations against Upcoming ALK-TKIs, Repotrectinib (TPX-0005) and Ensartinib (X-396)

The paper predicts resistant mutations against new ALK-TKIs, repotrectinib and ensartinib, using an error-prone PCR-based system, suggesting their potential as second-line treatments after alectinib.

Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

This study identifies a TMPRSS2-independent metalloproteinase-dependent entry pathway for SARS-CoV-2 that requires the furin cleavage site and S2 domain of the spike protein, highlighting new therapeutic targets.

Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

The paper identifies two cancer stem cell-like populations in TNBC xenografts using transcriptomic analysis and confirms their presence in patient data, suggesting potential as biomarkers and implications for drug resistance.

Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models

This study evaluates the metastatic abilities of HER2-positive breast cancer cell lines in xenograft models and identifies gene signatures associated with metastatic preferences.

Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer

This study identifies NIK upregulation in breast cancer due to translational dysregulation, which promotes tumorigenicity by activating the non-canonical NF-κB pathway.

HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

This study shows HOXB7 promotes transformation and lung metastasis in NMuMG cells via STAT3 activation.

The anticoagulant nafamostat potently inhibits SARS-CoV-2 infection in vitro: an existing drug with multiple possible therapeutic effects

This study shows nafamostat inhibits SARS-CoV-2 infection in vitro by blocking TMPRSS2-mediated fusion, with potency exceeding its blood concentration, suggesting it as a potential COVID-19 treatment.