Facile discovery of isonitrile natural products via tetrazine based click reactions
Abstract
A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. A in situ reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time.
02 /Specification & Classification
Click any tag to browse matching papers- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Isonitrile Formation by a Non-heme Iron(II)-dependent Oxidase/Decarboxylase
N. C. Harris, D. A. Born, … W. Zhang·bioRxiv·Apr 25, 2018
- Redox Activated Substrates for Enhancing Activatable Cyclopropene Bioorthogonal Reactions
W.-S. Kao, W. Huang, … S. T. Laughlin·bioRxiv·Oct 13, 2023
- Methylotroph Natural Product Identification by Inverse Stable Isotopic Labeling
D. A. Cummings, A. I. Snelling, A. W. Puri·bioRxiv·Apr 26, 2021
- A new heme enzyme family forms hydrazine groups in diverse biosynthetic pathways
Grace E. Kenney, Kwo-Kwang Abraham Wang, … Emily P. Balskus·bioRxiv·May 27, 2025
- Small Molecule in situ Resin Capture - A Compound First Approach to Natural Product Discovery.
A. Bogdanov, M. N. Salib, … P. R. Jensen·bioRxiv·Mar 2, 2023
- Qinichelins, novel catecholate-hydroxamate siderophores synthesized via a multiplexed convergent biosynthesis pathway
Jacob Gubbens, Changsheng Wu, … Gilles P. van Wezel·bioRxiv·Jul 13, 2017