experimental assay

This paper introduces SPress, a method that enables high-speed, high-contrast voltage imaging of large neuronal populations in vivo with mesoscopic resolution.

The paper uses single-cell transcriptomics to analyze brain cells in paper wasps, showing that Kenyon cells vary with social roles and respond to social interactions.

This study reconstructs a wild hunt by Portia labiata, suggesting it may have planned its route to avoid detection by prey.

This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.

This study identifies TIF1g as a regulator of TGF-b signaling in CD8+ T cells, showing it restricts expansion while preserving cytotoxic function.

This study evaluates how accessibility modifications in zoo enclosures affect meerkat behavior, finding increased use of low areas and more frequent species-appropriate sentry behavior.

This study shows that FBL-mediated 2'-O-methylation of GLTs forms condensates that drive IgH synapsis and CSR in B cells.

The paper examines lifespan changes in neural temporal dynamics using resting-state MEG data, finding distinct trajectories for cortical intrinsic timescales and alpha oscillations.

This study shows PARP1-mediated PARylation of SPRTN limits its DNA-protein crosslink repair activity by reducing DNA binding and proteolytic function.

This study measures confidence through a decision-making task and finds it is a state influenced by environmental factors rather than a driver of behavior.

This paper introduces ACE, a method to create genomic chimeras by integrating large genomic segments from donor cells into a recipient genome, demonstrating its ability to generate stable chimeric organisms across species barriers.

This study uses microfluidics to show that pancreatic tumor spheroids of different sizes exhibit distinct mechanical behaviors, with larger spheroids showing core-shell heterogeneity.

This study shows that head movements create a perceptual bias in the direction of a moving sound source, similar to visual motion illusions, revealing errors in integrating auditory and proprioceptive cues.

This study shows that vitamin B12, not iron, is the primary limiting nutrient for phytoplankton in the Southern Ocean, with implications for community composition and function.

The paper identifies ANKRD55 interacting with an IFT-B-like complex in microglia, suggesting a role in ciliary transport independent of ciliogenesis.

This study shows that increased cognitive load expands and stabilizes visual representations across the brain, enhances cross-regional coordination, and reduces neural variability.

This study shows that amyloid structure and condensate stability independently influence the hnRNPA2 condensate-to-fibril transition, revealing a structural framework for this process.

This study evaluates the ecotoxicological effects of transition metal-containing LDH nanoparticles on maize, tomato, and C. elegans, finding low phytotoxicity but greater toxicity in the nematode.

This study compares gliflozins and finds canagliflozin uniquely reduces vascular calcification through mechanisms beyond SGLT2 inhibition, affecting VSMC metabolism and calcification.

The paper estimates Madagascar's insect fauna contains at least 250,000 species, most unrecorded, and finds global homeostatic forces, not lineage composition, shape its ecological similarity to temperate forests.

This study shows that maltose enhances somatic embryogenesis in hybrid fir by promoting a mature biochemical profile with earlier raffinose synthesis and higher carbohydrate retention post-desiccation.

This study shows that deleting tyrosine hydroxylase in Ntsr1 neurons reduces diet-induced weight gain without increasing energy expenditure or activity.

This study uses OptoTet to manipulate TAD boundaries and shows that boundary pairing enhances gene activity for ERRFI1 but not MYC.

This study identifies two novel H3 histone variants in Hofstenia miamia that destabilize nucleosomes and promote chromatin accessibility during regeneration.

The paper exposes zygnematophyte algae to UV irradiance and identifies conserved molecular responses, including lipid droplets and phenolic compounds, suggesting a shared UV acclimation mechanism with land plants.

This study shows that past adaptation to systemic infection affects the speed and mechanism of adaptation to oral infection in Drosophila, with sex-specific outcomes and trade-offs.

This study develops a synthetic cleavage module that selectively degrades pathogenic r(CUG) repeats in cells, reducing DM1-associated pathology without DNA damage.

This study investigates how cardiac arrest affects myocardial ribosome biology and protein synthesis in pigs and mice, finding increased ribosomal transcripts with ischemic burden and suppressed ribosome activity post-arrest.

This study identifies a multipotent secretory cell population in mouse distal airways that contributes to both airway and alveolar regeneration after injury.

The paper introduces SMAUG, a semi-automated tool for analyzing actin filament dynamics from TIRF microscopy images, reducing analysis time while maintaining accuracy.