wet-lab / biochemical assay

This study identifies RPLP1 ribosome remodeling under glucotoxic conditions as a mechanism impairing beta-cell function and insulin secretion in diabetes.

This study identifies Contact-phagy as a selective autophagy pathway that targets ER-mitochondria contact sites for turnover under metabolic and mitochondrial stress.

The paper develops a C. elegans model to visualize subcellular architecture across adult life and identifies a midlife architectural state shift linked to aging and homeostatic challenges.

This study identifies SUMOylation and non-proteolytic ubiquitination as mechanisms regulating IRF2BP2 nuclear localization and stability through a SUMO1-NLS-importin-β pathway.

This study examines how gaze patterns and EEG reflect the temporal dynamics of multi-item working memory maintenance, finding stable gaze encoding and no rhythmic alternation between items.

This study develops a tetravalent dengue mRNA vaccine that induces broad, durable, and protective immunity across all four serotypes in mice.

This study identifies ASP as a modulator of host cell homeostasis through proteomics and functional validation, revealing its role in DNA repair and mitochondrial function.

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

The paper investigates experience-dependent plasticity in somatostatin interneurons and identifies two-pore potassium (K2P) channels as a mechanism underlying this plasticity.

This study develops a synthetic cleavage module that selectively degrades pathogenic r(CUG) repeats in cells, reducing DM1-associated pathology without DNA damage.