imaging

Disease-associated MYH11 tail variants disrupt vascular smooth muscle myosin II filament dynamics and cell mechanics

This study examines how disease-associated MYH11 variants affect SMII filament dynamics and VSMC mechanics through live-cell imaging, revealing distinct functional impacts of K1256del and A1839V variants.

Unstable word form representations and greater reliance on right hemisphere during word learning in adults with a history of developmental language disorder

This study examines word learning in adults with developmental language disorder (DLD) and typically developing (TD) controls, finding reduced recall and increased confusion in DLD participants, along with altered hemispheric involvement in word form processing.

When word order matters: human brains represent sentence meaning differently from large language models

This study compares how human brains and large language models represent sentence meaning, finding that transformers poorly match brain representations despite capturing some structural aspects.

Pediatric brain charts reveal ADHD biotypes with distinct developmental, molecular, and therapeutic profiles

The paper identifies two distinct ADHD biotypes using brain imaging and transcriptomic data, showing different developmental, molecular, and treatment responses.

Textures are less comfortable to view than other natural images, consistent with cortical hyper-metabolism theory

The paper finds that texture images are less comfortable to view than other natural images, supporting the Cortical Hyper-metabolism Hypothesis.

A method for correcting background non-uniformity while preserving specimen-level information in Fourier ptychographic microscopy images

This paper introduces a background correction method for Fourier ptychographic microscopy images that preserves specimen information and improves quantitative analysis.

A non-invasive approach to study localized forced in 3D epithelia

This paper introduces a non-invasive method to study localized mechanical forces in 3D epithelial tissues using elastic microbeads and shows how cytoskeletal remodeling and adhesion organization respond to mechanical perturbations.

The anger-insula-body link in heart arrhythmias

The paper investigates the link between anger, insula activity, and heart arrhythmias using multimodal data to show increased insula involvement and sympathetic activation in patients.

Low-order MLKL oligomers induce irregular membrane defects in necroptosis

This study shows that low-order MLKL oligomers cause irregular membrane defects during necroptosis, disrupting plasma membrane integrity without forming defined pores.

Ether-lipid deficiency remodels the testicular interstitium beyond spermatogenic arrest in Gnpat-knockout mice

This study shows that Gnpat-knockout mice exhibit testicular interstitial remodeling and germ-cell loss due to ether-lipid deficiency, with no DNA-damage checkpoint activation.

Task-general brain state dynamics relate to trial-to-trial performance and individual response strategy

The paper identifies recurring brain states across tasks and links their dynamics to trial-to-trial performance and individual response strategies.

Spatial profiling of Kawasaki disease cardiac inflammation identifies STING as a therapeutic target

This study identifies STING as a therapeutic target for Kawasaki disease by analyzing spatial immune architecture in cardiac inflammation.

Development of Neonatal Functional Brain Network Organisation and Its Association with Childhood Neurodevelopmental Outcomes

This study examines neonatal functional brain network organisation using fMRI and links it to childhood neurodevelopmental outcomes, finding associations with later difficulties in 4-6 year olds.

iFLiP: accessible and low-cost lifetime fiber photometry for robust longitudinal and quantitative measurements of neural dynamics

Far-Red Light Photoacclimation Rewires Antenna-Photosystem Organization in Cyanobacterial Cells

This study shows that far-red light induces structural changes in cyanobacterial thylakoids, reorganizing antenna-photosystem complexes and revealing persistent membrane heterogeneity.

A pilot computer-vision model trained to identify slide-mounted scale insect pests from the family Rhizoecidae

The paper trains a computer-vision model to identify 16 species of root mealybugs using high-resolution images from museum specimens, achieving 79% F1 score.

Aberrant cortical reorganization and astrogliosis underlie memory deficit post-traumatic brain injury: a longitudinal multiscale multimodal study

This study uses multiscale multimodal data integration in a mouse model of traumatic brain injury to identify biomarkers of memory deficits and network dedifferentiation.

Multiparametric MRI and imaging transcriptomics reveal brain-wide changes in GD3 synthase deficiency

The paper uses MRI and transcriptomic data from a GD3 synthase-deficient mouse model to identify molecular correlates of brain structural differences.

Progression of visual-stimulus-evoked blood velocity response timing across the vascular network measured with individual-vessel phase-contrast fMRA

This paper measures blood velocity response timing across the vascular network using dynamic PC-fMRA, showing arterial and venous responses with distinct temporal delays.

Pheromones induce visuomotor arousal in jumping spiders

This study investigates whether pheromones influence visual attention in jumping spiders, finding that pheromones increase body and eye movement but do not specifically prime attention toward congruent stimuli.

MYC targeted de novo binders impair tumor growth

Designed protein binders to conserved MYC regions reach low-nanomolar affinity, reduce MYC-MAX proximity in cells, and are depleted from MYC-dependent cancer cells in culture and mouse pancreatic tumors.

Microscale Characterization of Undecalcified Bone Tissue Using Correlative Atomic Force Microscopy and Histology

This study develops a method combining AFM and histology to analyze undecalcified bone tissue, revealing age-related changes in structure and stiffness in mice.

Olfactory combinatorial coding supports risk-reward decision making in C. elegans

This study shows that 1-octanol is encoded as both an attractant and repellant in C. elegans, with central integration determining behavioral response valence and sensitivity.

Anatomically Programmable and Optically Tunable 3D-Bioprinted Tumor-Mimicking Phantoms for Quantitative Nanofluorophore Benchmarking

This paper develops 3D-bioprinted tumor-mimicking phantoms to benchmark nanofluorophores under surgical conditions, showing their ability to evaluate fluorescence properties and guide tumor resection.

Task-evoked flexibility of intrinsic neural timescales is hierarchically organized, behaviorally relevant, and refined across two developmental stages

The paper shows that neural timescale flexibility adapts to task demands, is hierarchically organized, and develops through two stages in youth.

Myo1e/f regulate phagocytic podosomes to promote efficient cup closure in macrophages

This study shows that Myo1e/f regulate phagocytic podosomes and the phagocytic ring to ensure efficient cup closure in macrophages.

Multiquantal transmission supports dynamic synaptic strength in vivo

This study shows that multivesicular release dominates synaptic transmission in vivo, enhancing reliability and enabling non-binary signaling at single synapses.

Stress, Heartbeats, and Biases: Cardiac phase and acute stress modulate affective and spatial response bias.

This study examines how cardiac phase and acute stress influence affective and spatial response biases in decision-making tasks.

Individual Differences in Sustained Attention Tune Semantic Abstraction in Neural Encoding of Narratives

The paper investigates how individual differences in sustained attention affect neural semantic encoding of narratives using fMRI and LLM embeddings, finding that attention shifts representations toward gist-level formats.

Structured recurrence of latent neural processes predicts memory recognition performance

The paper shows that structured recurrence of neural processes predicts better memory recognition performance in auditory tasks.