imaging

Dual kinase inhibition provides early clues to restoration of neuroimmune homeostasis in an AAV-haSyn model of Parkinsons disease

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

Functional Data Clustering of Filopodia Dynamics

The paper clusters filopodia dynamics using functional data analysis to identify distinct temporal patterns linked to Notch signaling in fruit fly development.

Maximum Likelihood Localization Maps

This paper introduces a non-iterative method to create molecular probability maps from single-molecule localization data, preserving positional likelihood without coordinate-based rendering.

Organotchi: an open-source tool for the automated segmentation, morphological characterization, and longitudinal tracking of organoids

Organotchi automates segmentation and morphological analysis of neural organoids, quantifying features and tracking changes over time to improve quality assessment and downstream analysis.

Residual Hearing Loss After Chronic Cochlear Implantation in Guinea Pigs is Primarily Conductive

This study identifies middle ear dysfunction as the primary cause of residual hearing loss in chronically implanted guinea pigs, suggesting a conductive mechanism.

Beyond Terrestrial Carnivores: Olfactory Bulb Anatomy in a Semi-Aquatic Mammal

This study characterizes the olfactory bulb anatomy of the Asian small-clawed otter, revealing a highly developed main olfactory bulb and a small, neurochemically distinct accessory olfactory bulb.

Can a Tiny Brain Plan? Reconstructing a Predatory Detour inthe Jumping Spider Portia labiata

This study reconstructs a wild hunt of a jumping spider, suggesting it may have planned its route to avoid detection by prey.

Brief visual oddball events evoke CSF flow in the spinal canal

The paper measures CSF flow in the spinal canal using fMRI and finds it correlates with BOLD activity decreases and is provoked by visual oddball stimuli.

Distinct lifespan trajectories of cortical intrinsic timescales and neural oscillations

The paper examines lifespan changes in neural temporal dynamics using resting-state MEG data, finding distinct trajectories for cortical intrinsic timescales and alpha oscillations.

Confidence: Its Measurement, Relation to Behavior, and Neural Representation

This study measures confidence through a decision-making task and finds it is a state influenced by environmental factors rather than a driver of behavior.

Extensional Flow Microfluidics Reveal Size-Dependent Core-Shell Mechanical Heterogeneity in Pancreatic Tumor Spheroids

This study uses microfluidics to show that pancreatic tumor spheroids of different sizes exhibit distinct mechanical behaviors, with larger spheroids showing core-shell heterogeneity.

Quantitative live imaging reveals region-dependent medulloblastoma disseminationin the zebrafish brain

This study uses live imaging in zebrafish to show that hindbrain medulloblastoma cells spread more frequently than forebrain or midbrain tumors and that dasatinib reduces dissemination.

Increased Cognitive Load Expands, Stabilizes, and Aligns Visual Representation Across the Human Brain

This study shows that increased cognitive load expands and stabilizes visual representations across the brain, enhances cross-regional coordination, and reduces neural variability.

Generalizable sex differences in functional brain organization follow the cortical hierarchy in youth

The paper examines sex differences in functional brain connectivity across youth, finding that males show greater network integration while females show greater network segregation along the sensorimotor-association axis.

Persistent and recyclable myosin II minifilaments drive cortical contractility in the early C. elegans embryo

This study uses advanced microscopy to show that myosin II minifilaments persist and recycle in C. elegans embryos, contributing to cortical contractility through stable, static interactions with actin.

Reinforcement sculpts synaptic ensembles for operant dendritic control

This study shows how reinforcement learning modifies specific dendritic activity through synaptic plasticity, leading to the formation of task-relevant synaptic ensembles.

Sex-dependent and region-specific morphological adaptations in astrocytes following early-life stress

This study uses sparse eGFP labeling to compare astrocyte morphology across brain regions and sexes in mice, finding sex-dependent and region-specific changes after early-life stress.

Early AAV9-mediated SLC9A6 gene replacement preserves cerebellar structure and motor function in the shaker rat model of Christianson syndrome

This study evaluates AAV9-mediated SLC9A6 gene replacement in shaker rats, showing early treatment preserves cerebellar structure and motor function, while later treatment has diminishing effects.

Measuring neuronal input-output operations in vivo with random access projection microscopy

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

Temporal Structure in Resting-State fMRI under Marginal and Cross-Spectral Surrogate Controls

The paper evaluates temporal complexity measures in resting-state fMRI to identify disease-related changes, finding that real data show greater outliers than randomized controls.

Active eye modeling: a tool for estimating retinal image quality across the visual field in everyday life

This paper introduces active eye modeling to estimate retinal image quality across the visual field during everyday activities, finding that near work under dim lighting increases peripheral blur.

SNAzzy: an image processing pipeline for investigating global Synchronous Network Activity

SNAzzy processes and analyzes high-throughput microscopy data from Drosophila embryos to study synchronous network activity.

RhoGEF Solo regulates cell density-dependent keratin remodeling and desmosome maturation

This study shows that Solo regulates keratin-DSM interactions and DSM maturation in response to cell density through RhoGEF activity and actin remodeling.

hAM-pe soluble extract increases human keratinocyte HaCaT cell-line mobility in scratch assays

The paper shows that hAM-pe extract accelerates wound closure in HaCaT cells by enhancing cellular motion persistence rather than individual speed.

Clinical relevance of diffusion tensor imaging-based parameters estimated with deep learning: the effect of model retraining

This study evaluates how retraining deep learning models affects the statistical consistency of diffusion tensor imaging parameters in bipolar disorder, showing significant variability across models.

RadMultiBench: A Reproducible Dual-Task Benchmark Exposing the Limits of Pre-Trained Vision-Language Models Across Thoracic and Breast Imaging

RadMultiBench evaluates pre-trained vision-language models on medical imaging tasks, showing performance gaps in report generation and classification across thoracic and breast imaging.

A reporter mouse model to map RIG-I expression and function in vivo

This paper develops a RIG-I reporter mouse model to track RIG-I expression and function in vivo, revealing its tissue distribution and identifying alveolar macrophages as key sensor cells.

Midlife nonlinearities across scale in Biondi body amyloid formation in the human choroid plexus

The paper examines age-related accumulation of Biondi bodies in human choroid plexus epithelial cells, finding nonlinear increases in prevalence and load, and suggesting prion-like spread mechanisms.

Geometric Morphometrics of Pistillate Flowers in Astrocaryum sect. Huicungo (Arecaceae): Taxonomic Implications for the Peruvian Species

This study uses geometric morphometrics to analyze pistillate flower shapes in Peruvian Astrocaryum species, revealing taxonomic insights through quantitative shape analysis.

Dopamine synthesis capacity and tau pathology differentially modulate rest-to-task functional network dynamics

This study examines how dopamine synthesis and tau pathology affect functional brain network dynamics during rest and task performance in young and older adults.