metabolomics

This study engineers Saccharomyces cerevisiae to produce polyphosphate more efficiently by modifying metabolic pathways and growth conditions.

This study evaluates the effects of organic fertilizer substitution on Dendrobium officinale yield and medicinal quality, finding that 40% substitution optimizes both growth and active compound content.

The paper identifies a pre-transplant γδ T-cell effector signature associated with kidney allograft rejection using multi-omics data from transplant recipients.

This study shows that disrupting the amino acid stress response pathway reduces tumor growth in multiple aggressive cancers by targeting chronic metabolic stress adaptation.

This study shows that sodium arsenite requires additional mitochondrial or redox stress to cause dopaminergic neurotoxicity in C. elegans, but not fluoroacetic acid.

This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.

This study shows that cGAS integrates TLR signaling in platelets to drive thromboinflammation by sensing mitochondrial DNA.

The paper develops a method to link genes to metabolism by analyzing commonality in metabolite features associated with mQTLs, demonstrating its effectiveness through three case studies.

This study compares the effects of organic and inorganic fertilizers on huckleberry growth and nutritional content, finding that poultry manure enhances micronutrients more than urea, which boosts yield.

This study identifies AMD1-driven MTA production as a mechanism sustaining chemoresistance by enhancing PMN-MDSC immunosuppression.

The paper quantifies age-related biological dysregulation using metabolomics in older adults and shows it has distinct subsystems linked to health outcomes and DNA methylation.

DEEPNET-LLM predicts unknown metabolite structures from mass spectra by leveraging molecular neighborhoods, achieving high accuracy in de novo structure prediction.

This paper introduces an automated method using singular value decomposition to analyze NMR fraction libraries for molecular component identification and quantification.

The paper uses enzyme-constrained metabolic modeling to show that Picochlorum celeri's rapid growth at elevated CO2 is due to protein budget allocation, not enzyme abundance.

This study isolates and characterizes W. globosa-derived nanovesicles, demonstrating their neuroprotective effects against methylglyoxal-induced oxidative stress in vitro.

This study identifies nutrient dependencies of intestinal Klebsiella pneumoniae and develops a probiotic consortium to restrict its expansion.

This study characterizes the in vitro metabolism and in vivo pharmacokinetics of ent-verticilide, showing rapid NADPH-dependent depletion and CYP3A-mediated metabolism with low oral bioavailability.

The paper maps bacterial bile amidation by analyzing BSH transaminase activities and identifying BBAs in human samples.

This study shows that photosynthesis-derived carbohydrates sustain CuCl2-induced phytoalexin production in rice leaves, highlighting the role of light and sugar availability in this process.

This paper introduces NORIGAMI, a multi-omics pipeline that combines imaging and deep learning to analyze kidney aging, revealing age-related structural and molecular changes.

The paper uses a multi-modal platform to profile single-cell stress responses in human cell lines, finding a shared stress response program with cell-specific magnitude variations.

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

The paper quantifies phloem conduit geometry and carbohydrate concentrations in avocado plants during development, showing changes in phloem structure and transport efficiency.

This study shows that fucoxanthin protects mouse oocytes from postovulatory aging by activating NRF2 in cumulus cells, improving mitochondrial function and reducing oxidative stress.

This study identifies divergent brain pathology in preterm infants with NEC, showing distinct cellular and molecular changes in the pons and cerebellum.

The paper develops an in vitro MASH model to study metabolite crosstalk between Kupffer cells and hepatocytes, identifying itaconate as a key mediator of liver disease progression.

The paper shows that fatty acid desaturation, specifically DGLA, influences cellular decisions between ferroptosis and senescence, with implications for aging and obesity.

This study uses metabolomics to show that UFP and aircraft noise exposure cause sex-specific metabolic changes in mice, with AN having the greatest impact and combined exposure showing sex-dependent effects.

This paper introduces Full Scan enhanced Dynamic Range MS to improve metabolite detection in untargeted metabolomics, increasing feature detection and enabling better discrimination between cancer cell lines.

This study identifies spatial developmental reprogramming in roots of Schrenkiella parvula under salinity, revealing distinct zones and regulatory programs that enable continued growth.