metagenomics
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1,000+ papers
- MicrobiologybioRxivPreprint
Oysters from five continents harbour a vast array of previously unknown RNA viruses, including many putative viruses of vertebrates
Kevin Xu Zhong, Amy M. Chan, Curtis A. Suttle
The paper characterizes the RNA virome of oysters from five continents, identifying many previously unknown viruses, including those potentially infecting vertebrates.
DOI 10.64898/2026.09.29.755536 - EcologybioRxivPreprint
Precipitation seasonality and soil carbon shape Arcellinida diversity across Bulgaria's ecosystems
Ángel García-Bodelón, Milcho Todorov, Nura ElKhouri-Vidarte…·Enrique Lara
This study examines Arcellinida diversity across Bulgaria's ecosystems, finding that stable humidity and intermediate soil carbon stocks enhance richness, while acidic peatlands host unique taxa.
DOI 10.64898/2026.09.29.755277 - EcologybioRxivPreprint
Ectomycorrhizal fungi associated with mature white spruce (Picea glauca ) across three Alaskan treelines
Kristina V. Kuprina, Saroj Basnet, Manuela Bog, Martin Schnittler
The paper examines root-associated fungal communities of white spruce trees across Alaskan treelines, finding that site and soil pH strongly influence fungal composition, while treeline effects are context-dependent and not linked to tree growth.
DOI 10.64898/2026.08.20.745949 - EcologyRoyal Society Open SciencePeer-reviewed
Ecological drift in the flour beetle microbiome and associated instability in host benefits
Pratibha Sanjenbam, Harshith Koppa Guruswamy, Rittik Deb…·Deepa Agashe
The paper examines microbiome instability in red flour beetles, showing ecological drift driven by environmental factors and its impact on host fitness benefits.
1 citation - BioinformaticsbioRxivPreprint
Evaluating Clustering and Imputation Approaches for Multivariate Longitudinal Clinical Data Using a Real-World eCDF-Copula Resampling Framework
Hanchang Cai, Ke Xu, Sarrah Osmundson…·Xinlian Zhang
The paper evaluates clustering methods for multivariate longitudinal data using a real-world eCDF-Copula resampling framework to address missing data and improve benchmarking.
DOI 10.64898/2026.09.24.753982 - BioinformaticsbioRxivPreprint
MGM2 as a Multimodal Foundation Model for Microbial Community States and Responses
Haohong Zhang, Yuli Zhang, Yuxuan Qi…·Kang Ning
The paper introduces MGM2, a multimodal foundation model for microbial communities that predicts responses to interventions and interprets community changes using shared representations of molecular identity and context.
DOI 10.64898/2026.07.20.739063 - MicrobiologybioRxivPreprint
Leveraging genomes and metagenome-assembled genomes unveils novel diversity and transmission between public transport and clinical settings in Acinetobacter
Rafael López-Sánchez, Alejandro Aguilar-Vera, Santiago Castillo‐Ramírez
This study combines metagenome-assembled genomes and clinical genomes to reveal Acinetobacter diversity and transmission between public transport and clinical settings, identifying antibiotic resistance genes across multiple species.
DOI 10.64898/2026.09.29.755473 - NeuroscienceEpilepsiaPeer-reviewed
The Ketogenic Diet Fails to Mitigate Seizures and Neuroinflammatory Responses in a Mouse Model of Virus-Induced Epilepsy
Casey H. Meili, Kaitlyn Allen, Daniel Jason Doty…·Ana Beatriz DePaula-Silva
This study shows the ketogenic diet does not reduce seizures or neuroinflammation in a virus-induced epilepsy mouse model, despite altering gut microbiota.
DOI 10.1002/epi.70509 - Evolutionary BiologybioRxivPreprint
Ecological stability masks rapid, convergent evolution within the honey bee worker microbiome
Chris R. P. Robinson, Adam G. Dolezal, Irene L. G. Newton
The paper uses longitudinal metagenomics to show rapid, convergent evolution in honey bee worker microbiomes despite ecological stability.
DOI 10.64898/2026.09.24.754198 - BioinformaticsbioRxivPreprint
Mediation Analysis with Compositional Exposures
Jing Ma, Poorbita Kundu, Timothy W. Randolph…·Meredith A.J. Hullar
The paper introduces a latent variable mediation framework to analyze the gut microbiome's indirect effects on clinical outcomes through compositional data structures.
DOI 10.64898/2026.09.24.754147 - BioinformaticsbioRxivPreprint
Detecting Random Mutations in 16S rRNA Sequences
Rain M Haworth, Seth Commichaux, Mihai Pop
The paper develops classifiers to detect modified 16S rRNA sequences that pass SILVA database quality controls by using conserved motifs and achieves over 90% sensitivity and specificity.
DOI 10.64898/2026.09.24.753821 - MicrobiologybioRxivPreprint
Anti-defense systems of viral communitie vary with genomic traits, host immunity and environmental stress
Dan Huang, Yiyan Yang, Ruonan Wu…·Pingfeng Yu
The paper investigates how viral anti-defense systems vary with genomic traits, host immunity, and environmental stress across microbial ecosystems.
DOI 10.64898/2026.09.28.755093 - EcologybioRxivPreprint
Exploring nematode diversity in soils: comparison of extraction methods and sequencing protocols
Marco Fioratti Junod, Sabine Brodbeck, SOPHIE C. GOMBEER…·Irene Cordero
This study evaluates how different extraction methods and sequencing protocols affect nematode biodiversity metrics in soil samples.
DOI 10.64898/2026.09.29.755246 - BioinformaticsbioRxivPreprint
Schistosoma mansoni infection enhances insertion sequence activity in the host gut microbiome
Yi-Hsuan Lee, Gabriel Rinaldi, Alba Cortés…·Martin Swain
This study shows that Schistosoma mansoni infection increases insertion sequence activity in the gut microbiome of mice, suggesting enhanced microbial genome plasticity.
DOI 10.64898/2026.09.23.753824 - EcologyMolecular EcologyPeer-reviewed
Validating wing biopsies for blood-borne pathogen characterization in bats
Molly C. Simonis, Amanda Vicente‐Santos, Lauren R. Lock…·Daniel J. Becker
This study evaluates the reliability of using wing biopsies to detect blood-borne pathogens in bats, finding lower detection rates compared to blood but still viable for initial pathogen discovery.
DOI 10.1111/mec.70560 - MicrobiologybioRxivPreprint
Soil viral response to drought disturbance and ecosystem recovery in an artificial rainforest
María Touceda-Suárez, Alise J. Ponsero, Linnea K. Hernandez…·Laura K. Meredith
This study examines how soil viral communities respond to drought and recovery in an artificial rainforest, finding they are more influenced by soil heterogeneity than moisture changes.
DOI 10.64898/2026.09.28.755132 - MicrobiologybioRxivPreprint
The two-component microbial system of the black soldier fly larvae (BSFL) gut: a plastic microbiota in the midgut, but a stable one in the hindgut
Maurielle Eke, Kévin Tougeron, Manon Martin…·François Renoz
This study investigates the gut microbiota of black soldier fly larvae, revealing a plastic midgut microbiota and a stable hindgut microbiota, with implications for their polyphagous behavior.
DOI 10.64898/2026.09.26.754629 - MicrobiologybioRxivPreprint
Determinants of gut microbiome composition and its response to a dietary intervention in a multi-ethnic cohort: a pop-up village study
Jagan L, Sneha Upreti, Aditi MUGLIKAR…·Ohad Manor
This study examines factors influencing gut microbiome composition and its response to a dietary intervention in a multi-ethnic cohort living in a shared environment.
DOI 10.64898/2026.09.16.751977 - MicrobiologybioRxivPreprint
Genome-resolved ecology and evolution of the microbiome enabled by quantitative long-read metagenomics
M. Omar Din, Caitriona Brennan, Jianshu Zhao…·Rob D. Knight
This paper introduces LRQ, a long-read metagenomics method that enables absolute strain abundance measurement and resolves microbial evolution in a Crohn's disease patient over eight years.
DOI 10.64898/2026.09.28.754546 - BiophysicsbioRxivPreprint
Lipid-Protein Reciprocal Coupling: A Quantitative Analysis of Membrane Curvature, Architecture, and Protein Association
Md Sorique Aziz Momin, Debanjan Sarkar, Nayan De…·A.B. Sannigrahi
The paper quantitatively analyzes lipid-protein interactions, showing how membrane curvature and composition influence protein association and function, and highlights new tools for studying these relationships.
DOI 10.64898/2026.09.24.751570 - MicrobiologybioRxivPreprint
The Ocean Microbiomics Database reveals thermal niches and projected pressure on marine microbes in a warming ocean
Samuel Miravet‐Verde, Hans‐Joachim Ruscheweyh, Kang Li…·Shinichi Sunagawa
The paper introduces the Ocean Microbiomics Database (OMDB) to analyze microbial thermal niches and predict their response to ocean warming, showing richness declines faster than abundance.
DOI 10.64898/2026.09.28.755000 - Synthetic BiologybioRxivPreprint
Coupled enzyme discovery, evolution and synthetic yeast chassis adaptation for microbial biopolymer valorisation
María del Carmen Sánchez Olmos, Jacob Gonzalez Isa, Nicole Paczia…·Daniel Schindler
This paper presents a coupled strategy for enzyme discovery, evolution, and yeast chassis adaptation to improve microbial biopolymer valorisation, demonstrating it with laccases for lignin depolymerisation.
DOI 10.64898/2026.09.28.754783 - MicrobiologyApplied and Environmental MicrobiologyPeer-reviewed
Microfluidic-based high-throughput isolation enhances the recovery of novel strains and diversity from Arctic soil microbiome
Li Liao, Tingyi Lai, Wanning Jiang…·Siqi Zhang
This study compares microfluidic droplet technology (MDT) with conventional plate methods (CPM) for isolating Arctic soil microbes, finding MDT significantly improves recovery rates, taxonomic richness, and evenness.
DOI 10.1128/aem.01124-26 - MicrobiologybioRxivPreprint
A microbiota-derived protease links phage susceptibility to host epithelial responses
Ning Qu, Marlène S. Birk, Thomas C. A. Hitch…·Joel Selkrig
This study identifies a bacterial protease that influences phage susceptibility and links it to host epithelial responses in ulcerative colitis.
DOI 10.64898/2026.09.26.754296 - Systems BiologybioRxivPreprint
Quantifying Chemical Fluxes Underlying Gut Microbiota-Host Interactions
Jonas Cremer, Markus Arnoldini
The paper quantifies chemical fluxes between gut microbiota and host by identifying measurable host parameters that influence flux magnitudes.
DOI 10.64898/2026.09.27.754802 - EcologyBiotropicaPeer-reviewed
Urban Environments Reshape Reproductive Phenology in Plants Across the Tropics
Rohit Raj Jha, Anita Simha, Richard Ekeng Ita…·Gaurav S. Kandlikar
This study uses iNaturalist and herbarium data to show urban areas in the tropics have longer plant reproductive durations and weaker seasonality compared to rural areas.
DOI 10.1111/btp.70272 - BioinformaticsMicrobiology SpectrumPeer-reviewed
Integrative holo-omic data analysis predicts interactions across the host-microbiome axis
Jenny Merkesvik, Jorge Langa, Carlotta Pietroni…·Torgeir Rhoden Hvidsten
The paper integrates holo-omic data from porcine hosts and gut microbiomes to predict host-microbiome interactions, identifying both known and novel relationships.
DOI 10.1128/spectrum.00263-26 - Cell BiologybioRxivPreprint
A Novel PD-L1 Splice Isoform Modulates β Cell Communication in Response to Interferon Signaling
Chaitra Rao, Fei Huang, Saptarshi Roy…·Emily Kristen Sims
The paper identifies an IFN-induced PD-L1 splice variant, PD-L1Δ3, which is retained intracellularly and fails to suppress T cell activation, altering β cell immune communication in type 1 diabetes.
DOI 10.64898/2026.09.25.754099 - EcologybioRxivPreprint
Does host diversity beget microbiome diversity? Effects of zooplankton diversity and composition on environmental and host-associated microbes
Joshua H. Dominguez, Christopher B. Wall, Margaret Y. Demmel, Jonathan B. Shurin
The paper investigates how zooplankton diversity and composition affect host-associated and environmental microbiomes, finding contrasting effects on microbiome diversity depending on host species.
DOI 10.64898/2026.09.25.754487