proteomics

Molecular mechanism of Aurora-A binding and activation by hnRNPK

This study identifies the molecular mechanism by which hnRNPK activates Aurora-A kinase through specific residue interactions in the Y-pocket.

HSF1 inhibition potentiates the antifungal activity and proteome instability induced by the fungal Hsp110 inhibitor 2H

This study shows that combining HSF1 inhibition with Hsp110 inhibitor 2H enhances antifungal activity by increasing proteome instability in fungal pathogens.

Progranulin deficiency promotes neuroinflammation through cathepsin B-mediated activation of the NLRP3 inflammasome

This study shows that progranulin deficiency increases NLRP3 inflammasome activity via cathepsin B, leading to neuroinflammation, and demonstrates that ASO treatment can reverse this effect in GRN-deficient cells.

Large-scale exposure of southern seabirds to avian cholera Pasteurella multocida: scavengers as sentinels at different spatial scales

The paper screens seabird species for antibodies against avian cholera bacteria to assess spatial distribution and identify potential sentinels for disease monitoring.

Deciphering auditory neuroprogenitor stemness for large-scale neuronal screening

The paper characterizes the molecular and metabolic changes in auditory neuroprogenitors induced by CHIR-DS treatment and demonstrates their utility in neuronal screening.

A Framework for Comparing Mouse Neoantigen Immunogenicity

Experimental pMHC melting-temperature stability ranked in vivo CD8+ T cell responses of 25 mouse neoantigens better than affinity assays or nine in silico predictors.

ZFP36 is a post-transcriptional regulator of the P2X4 receptor in myeloid cells

The paper identifies ZFP36 as a post-transcriptional regulator of P2X4 receptor expression in myeloid cells, revealing a novel mechanism linking myeloid cell state to purinergic responsiveness.

Sexual reproduction impacts vertebrate organ aging

This study shows that lifelong mating in killifish affects liver aging in a sex-specific manner and is associated with younger transcriptomic and proteomic ages in humans.

HIV-1 envelope glycan loss links receptor adaptation and innate immune escape in SHIVs

This study shows that HIV-1 envelope glycan loss in SHIVs improves CD4 receptor utilization and reduces IFN restriction, linking receptor adaptation and immune escape.

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention

This study identifies altered thick ascending limb cells with UMOD retention as drivers of CKD using spatial proteomics and shows reducing UMOD retention attenuates CKD development.

Predicting cyanobacterial oxic diazotrophy and prioritizing candidate protein families beyond known Nif proteins

The paper predicts cyanobacterial diazotrophy using protein-family content and prioritizes candidate protein families for experimental validation.

NE52-QQ57 attenuates post-ischemia protein phosphorylation in the mouse brain

This study shows that NE52-QQ57 reduces post-ischemia protein phosphorylation and crosses the blood-brain barrier in mice.

Serotype-independent inhibition of S. pneumoniae by SMiTE, a commensal-derived bacteriocin

The paper identifies SMiTE, a commensal-derived bacteriocin that effectively inhibits multiple Streptococcus pneumoniae serotypes without harming commensals.

Spatiotemporal profiling of T cell repertoires in Lynch syndrome reveals convergent immune responses through neoplastic progression

This study profiles T cell repertoires in Lynch syndrome patients to show convergent immune responses during neoplastic progression.

Identification of the Col4a3-/- mouse as a model of chronic kidney disease-associated cachexia

The paper identifies the Col4a3-/- mouse as a model of CKD-associated cachexia, showing significant weight loss, muscle atrophy, and systemic inflammation.

DTCAMD, a disease-associated truncated form of CRYAB in neovascular age-related macular degeneration: a potential driver of subretinal fibrosis

This study identifies a truncated form of CRYAB, DTCAMD, as a potential therapeutic target for subretinal fibrosis in nAMD.

The immunogenic 33-mer gliadin peptide attenuates flagellin-induced TLR5/NF-κB signaling

The paper investigates how 33-mer gliadin nanostructures affect TLR5/NF-κB signaling in Caco-2 cells, showing they inhibit flagellin-induced activation.

Five decades of human H1N1 evolution reveal conserved glycan receptor specificity

This study examines the evolution of H1N1 influenza viruses over five decades, revealing conserved glycan receptor specificity despite amino acid changes in the hemagglutinin.

A Multi-Omic Phenobank Reveals Axes of Glioblastoma Growth, Invasion, and Therapeutic Vulnerability

The paper establishes a multi-omic PDX resource linking GBM invasion phenotypes to molecular programs and therapeutic responses, identifying two invasion modes and a neurodevelopmental factor associated with tumor growth and survival.

Revisiting Hydractiniidae (Hydrozoa): Mitogenomic Insights into the Diversity, Systematics and Life-Cycle Evolution of North Atlantic and Arctic Species

This study uses mitogenomic and morphological data to reassess hydractiniid diversity, species boundaries, and life-cycle evolution in North Atlantic and Arctic species.

Trastuzumab deruxtecan kills skin and uveal melanoma in vivo by HER2-independent payload release

This study shows trastuzumab deruxtecan (T-DXd) effectively kills melanoma in vivo, even when HER2 is not expressed, due to extracellular cathepsin L-mediated payload release.

How Bacterial Growth-Phase Reshapes Synthetic Gene Circuit Function

This study develops a mathematical model to predict synthetic gene circuit function during bacterial stationary phase by measuring transcription and translation dynamics over time.

A monoallelic immunopeptidome atlas of 10 prevalent canine DLA-88 alleles

The paper generates a monoallelic immunopeptidome atlas for 10 prevalent canine DLA-88 alleles, identifying 32,702 peptides and revealing allele-specific binding motifs and conserved antigen-processing signatures.

Pre-neuronal origins of monoamine and acetylcholine synthesis and transport

This study identifies the evolutionary origins of neurotransmitter synthesis and transport in fungi, showing these functions predate neurons and are linked to lysosomal processes in opisthokonts.

Single Cell Proteomics reveals partial uncoupling of the Glycerol-3-Phosphate shuttle to compensate for Electron Transport Chain dysfunction in Alexander Disease GFAP mutations

The paper uses single-cell proteomics to show that GFAP mutations in Alexander disease lead to ETC dysfunction and metabolic adaptation via the G3P shuttle.

In Vitro Assessment of Chemically Modified Probiotic Bacteria as Receptor-Mimic Decoys for Cholera Toxin B Subunit

This study develops GM1-receptor-mimic probiotic bacteria that bind and sequester cholera toxin B subunit in vitro, reducing its binding to host cells.

Radiotherapy Reshapes the 3D Genome in Medulloblastoma Cells

This study examines how radiotherapy affects the 3D genome of medulloblastoma cells, identifying molecular and structural changes associated with radiation response.

Host-secreted lactate during respiratory viral infection diminishes macrophage antibacterial activity through metabolic reprogramming

This study shows that host-secreted lactate from viral-infected airway epithelial cells reduces macrophage antibacterial activity by reprogramming their metabolism.

p70 ribosomal protein S6 Kinase (p70S6K) as a potential peripheral biomarker for autistic symptoms in 16p11.2 deletion and duplication syndromes

The paper identifies reduced p70S6K levels in PBMCs of individuals with 16p11.2 deletion and duplication syndromes, correlating with autistic symptom severity.