cancer & tumor microenvironment

This paper introduces LACO-Stim, a co-stimulatory molecule that enhances CAR-T cell therapy by reprogramming the tumor microenvironment to support endogenous anti-tumor immunity.

This study shows BCL10 gain-of-function mutations prevent naive B cells from entering germinal centers and cooperate with BCL6 to cause extrafollicular diffuse large B-cell lymphoma.

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

This study identifies chromothripsis as a common driver of pleural mesothelioma, linked to gene deletions and poor patient survival.

This study shows that varying the number of tumor cells implanted affects the tumor microenvironment, with implications for disease progression and therapeutic response.

P-selectin-targeted fucoidan nanoparticles carrying Navitoclax or dBET6 deplete a senescent-like, lipid-associated macrophage subset, reverse mouse liver and lung fibrosis with less toxicity, and restore checkpoint therapy response in fibrotic tumors.

This study shows ARID2 loss destabilizes the PBAF complex, leading to CRC progression through disrupted chromatin remodeling and pathway perturbations.

This study identifies SRPK1 as a key regulator of docetaxel resistance in prostate cancer by modulating splicing and apoptosis pathways.

Short-term palbociclib exposure during a premalignant risk window delays ErbB2-driven mammary tumorigenesis by suppressing stemness and proliferation.

This study compares the effects of HrasG12V and KrasG12D mutations in thyroid cancer, showing HrasG12V induces follicular thyroid cancer with delayed MAPK activation and longer latency.

This study shows ALK variants differentially affect neuroblastoma tumor behavior and transcriptome depending on the cellular context.

This study identifies a developmental GAL1-glycan program that promotes early breast cancer dissemination and metastasis by reactivating mammary stem cell traits and epithelial plasticity.

This study shows that TNBC cells surviving ionizing radiation adopt an OPA1-dependent mitochondrial reprogramming that supports their survival and regrowth.

This study tracks somatic mutation evolution in hair follicles to forecast early skin cancer development non-invasively.

This paper identifies an EZH2-driven immune evasion phenotype in FUS::ERG AML that is reversible with tazemetostat, offering a potential targeted therapy for high-risk acute leukemia.

This study shows Menin inhibition reduces metastatic colonization of Ewing sarcoma in vivo by disrupting MYC target gene expression and Menin:MYC interactions.

The paper shows that inhibiting RhoA-mediated secretory autophagy in megakaryocytes reduces cytokine secretion and fibrosis in a mouse model of myelofibrosis.

This study identifies NAT10 as a suppressor of tumor-intrinsic immunity in HNSCC, showing that its inhibition enhances immune responses and suppresses tumor progression.

This paper identifies a chromatin-altered subtype of urothelial carcinoma defined by SWI/SNF alterations, showing it is sensitive to HDAC inhibition and immunotherapy.

This study shows that loss of TDP-43 causes premature aging in skeletal muscle stem cells, reducing their regenerative capacity and leading to muscle degeneration.

This study shows that in vitro-derived cDC1s resemble tumor-infiltrating DCs and that MHC-I and MHC-II antigen presentation by these cells is essential for effective cancer immunotherapy.

This study shows that aging-related changes in cysteine posttranslational modifications alter protein phase separation, leading to aggregation and neurodegeneration.

This study shows that heterogeneous radiation dose in tumors enhances anti-tumor immunity and correlates with better clinical outcomes in prostate cancer patients.

This study shows that IGF2BP family proteins suppress RNA-sensing pathways by binding TNFAIP3 mRNA, reducing innate immune signaling in AML cells.

This study identifies BMAds as drivers of prostate cancer bone metastasis through lipid-mediated induction of ANGPTL4, showing its clinical relevance as a therapeutic target.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This study identifies the basal cell state in pancreatic cancer as critical for maintaining tumors through an immunosuppressive circuit, showing its ablation leads to tumor collapse.

This study identifies BPA-induced changes in placental phosphoproteome and kinase activity, revealing altered phosphorylation of c-JUN and GSK3 linked to placental toxicity and adverse pregnancy outcomes.

This study shows that combined inhibition of autophagy and exosome pathways reduces cancer cell proliferation, with GABARAPL2 regulating Alix expression to control exosome secretion.