development & morphogenesis

Site-, strain- and mutation-specific osteopetrosis phenotypes in mice with Clcn7 variants

This study examines how Clcn7 mutations in mice affect bone phenotypes, showing increased trabecular bone mass with variations based on age, sex, genetic background, and mutation type.

Physiological caffeine concentrations do not affect enteric neural crest cell migration in a mouse model

This study shows that physiological caffeine doses do not impair enteric neural crest cell migration in a mouse model, suggesting caffeine is not directly responsible for Hirschsprung disease risk.

A topoietic model of collective morphogenesis and compartmentalization

The paper introduces topoiesis, a mechanism where diffusion and geometry drive collective morphogenesis and survival in Xenopus embryos under stress.

The bHLH121-CAT2 module maintains root tip redox homeostasis to confer salt tolerance additively with the SOS pathway in Arabidopsis

This study identifies the bHLH121-CAT2 module as a novel regulatory pathway that maintains root tip redox homeostasis and enhances salt tolerance in Arabidopsis independently of the SOS pathway.

Systematic comparison of genetically encoded F-actin probes for visualizing actomyosin dynamics in vivo using C. elegans

The paper compares three F-actin probes in C. elegans, finding mStayGold offers best brightness and photostability, while mNeonGreen is suitable for photobleaching applications.

Rapid Electro-optic Two-photon Bessel Light Sheet Fluorescence Lifetime Imaging for Tissue Volume Interrogation

This paper introduces a new two-photon fluorescence lifetime imaging technique for rapid volumetric imaging of biological samples with high resolution and low phototoxicity.

Intrinsic timekeeping in Escherichia coli

This study shows Escherichia coli has an intrinsic timekeeping system that anticipates daily temperature cycles through rhythmic curli plaque formation.

Neural Crest-Derived Endocardial Cells Required for Heart Valve Development

The paper identifies a rare population of neural crest-derived endocardial cells essential for heart valve development in mice and humans, showing their role in valve morphogenesis through Pthlh signaling.

CD90 identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance

The paper identifies CD90 as a marker distinguishing two muscle stem cell subpopulations with different activation kinetics and quiescence maintenance mechanisms in mice and humans.

Nutrient-responsive midgut turnover is spatially controlled by serotonin signaling

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

mTORC1-dependent control of Hedgehog signaling mediates nutrient-responsive licensing of intestinal stem cell differentiation

This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.

The role of the fruitless P3 transcript in development in Drosophila melanogaster

This study investigates the role of the fruitless P3 transcript in Drosophila development, finding it essential for pupal development and metamorphosis, with distinct effects compared to complete fruitless loss.

A subtype-specific gene regulatory program controls differential circuit integration of deep CA3 pyramidal neurons

The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.

Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation

This study investigates the role of anionic lipids in etioplast-to-chloroplast differentiation, finding that phosphatidylglycerol is crucial for membrane processes while sulfoquinovosyldiacylglycerol supports chloroplast development under PG limitation.

The chloroplast-localised transporter RETICULATA controls palisade mesophyll cell division and expansion

This study identifies the chloroplast transporter RETICULATA as a regulator of palisade mesophyll cell division and expansion, influencing leaf air space patterning.

An orphan LuxR regulator controls plant developmental reprogramming during interaction with Novosphingobium resinovorum HR1a

This study identifies LuxR874 as a bacterial regulator that modulates plant developmental reprogramming during rhizoremediation by altering host gene expression and physiological responses.

Feeding experiments with Senegal bichir Polypterus senegalus provide evidence for diet-related tooth damage and dental microwear

This study shows that diet affects tooth damage and microwear in Senegal bichir, providing a framework for inferring diet in extinct fish species.

PPI-Rescue: restoration of eye development via functional reconstitution of a transcription complex.

PPI-Rescue restores eye development by reconstituting transcription complexes in Drosophila using targeted mutations and cofactor interactions.

Parallel and lineage-dependent mitonuclear evolution in threespine stickleback

This study examines parallel evolution of nuclear OXPHOS genes in threespine stickleback across freshwater populations and identifies mitonuclear evolutionary coupling in specific functional modules.

Phosphate-responsive ornithine lipid biosynthesis remodels outer membrane composition and contributes to polymyxin tolerance

This study identifies OlsF-dependent ornithine lipid biosynthesis as a phosphate-responsive pathway that remodels the outer membrane and enhances polymyxin tolerance in Enterobacterales.

A transient pulse of neuronal ATF4 installs a durable non-autonomous programme promoting healthy ageing

This study shows that transient ATF4 activation in neurons during early adulthood extends healthspan and promotes systemic adaptations in Drosophila.

Podoplanin shapes epidermal morphogenesis and coordinates stem cell and epidermal-dermal responses during inflammatory remodelling

This study identifies podoplanin's role in maintaining epidermal organisation and coordinating stem cell and dermal responses during inflammatory skin remodelling.

Lung Epithelial TLR7 is a Factor in Viral Replication and Pathogenesis

This study shows that TLR7 in lung epithelial cells drives RSV and influenza replication and disease, but not HPIV3, and links TLR7 expression to sex differences in viral disease.

Basal ganglia output guides decision-making by state destabilization

The paper shows that basal ganglia output in zebrafish destabilizes neural activity states to guide decision-making in a Go/No-go task.

Physical sensorimotor contingencies facilitate learning in monkeys

This study shows that rhesus monkeys learn maze-solving tasks significantly faster in a physical environment than in a virtual one, with limited performance transfer between the two.

Calves function as social magnets in a species with high fission-fusion dynamics, the Asian elephant

The study finds that calf presence in Asian elephant groups increases group size and social associations, suggesting calves promote sociality through collective defense and allomaternal care.

Gene expression in Anolis sagrei suggests conservation of patterning mechanisms drives formation of two high acuity areas

The paper identifies conserved gene expression patterns in the retina of Anolis sagrei that suggest shared developmental mechanisms for forming multiple high acuity areas.

Biological Signaling Pathways Associated with Late Tendon Development in Chicken Embryos and Their Dependence on Mechanical Stimulation

This study identifies mechanotransduction pathways involved in chicken tendon development and shows how paralysis disrupts these processes.

Removal of maternal compensation reveals retinal-specific roles for Pomgnt1 in zebrafish

This study shows that removing maternal compensation in zebrafish reveals retinal-specific roles for Pomgnt1, with retinal abnormalities appearing early and behavioral changes observed.

Making sense of chaos: replication and segregation defects in the yeast mcm4Chaos3 mutant

The paper investigates the mcm4Chaos3 mutation in yeast, showing it causes genome instability by impairing specific centromere-proximal origins.