perturbation response prediction

The paper develops a degrader that specifically targets oncogenic fusions in cancer cells, showing efficacy in preclinical models and enhanced therapeutic effect when combined with siRNA.

This study evaluates KAT/3BP, a 3BP derivative, showing in vitro and in vivo anti-tumor activity against lymphoma models, including resistant cell lines and synergistic effects with existing therapies.

This study examines how physical and perceived brightness influence breakthrough time under continuous flash suppression, finding that unconscious processing of brightness illusions occurs without expediting awareness.

The paper develops a 3D bioprinted bone model from patient-derived cells to study donor-specific therapeutic responses to DKK1Ab in osteogenesis imperfecta.

This paper scales large language models for single-cell analysis, improving predictive and generative capabilities and enabling biological discovery through virtual screening.

The paper investigates how spacer sequences between a promoter and A2UCOE affect gene expression leakage and silencing in iPSCs, finding that an AT-rich poly-A terminator reduces leakage and enhances anti-silencing.

This study shows that motor cortex dynamics in macaques adapt to moving targets, leading to reduced reaction time delays from perturbations compared to static targets.

The paper introduces Bioflex, a microfluidic technique for isolating single bacterial cells in permeable microcapsules to study their responses to environmental changes like antibiotics.

This paper introduces a method to improve cancer prognosis by analyzing cell-type specific epigenetic alterations, finding better prognostic models in liver and kidney cancer.

This paper introduces DREDGE, a method using CRISPR-associated endoribonucleases to regulate gene expression by targeting direct repeats in the 3' untranslated region, achieving up to 90% downregulation in a reversible manner.

The paper introduces a method to control protein activity through dimerization-based conditional reconstitution, demonstrating its application in inducing cell death, virus detection, and immune cell stimulation.

This study develops optogenetic tools to control Nodal signaling patterns in zebrafish embryos, enabling precise spatial manipulation of signaling activity and rescue of developmental defects.

The paper investigates the interaction between BET proteins and the pre-replication complex in cancer cells, showing that combining BET and CDC7 inhibitors enhances therapeutic effects through DNA damage and genomic instability.

This study shows that combining FAK and PI3K inhibitors synergistically suppresses cervical and pancreatic cancer cell growth by increasing apoptosis and reducing mitosis.

This paper introduces DGRec, a method using DGRs to enable targeted hyper-mutagenesis in E. coli, creating diverse variants that allow evasion of phage infection.

The paper improves the FLARE system to better record and manipulate neuronal activity by enhancing calcium sensitivity and signal-to-background ratio in Drosophila models.

This study uses genome-scale CRISPR screening to identify LDLR and MYLIP as key regulators of Lp(a) uptake in HuH7 cells, with validation in a UK Biobank cohort.

This study validates the palmitoylation cycle as a therapeutic target in NRAS-mutant cancers by showing that inhibiting ABHD17 reduces tumor growth and synergizes with MEK inhibitors.

The paper creates a multi-omic atlas of human neural organoids modeling the posterior brain and identifies morphogen conditions that expand organoid models.

This paper develops optogenetic tools to induce membrane rupture of specific organelles using engineered BAX proteins with light-sensitive domains.

The paper uses in vivo single-cell CRISPR screening in mouse epidermis to identify a microprotein critical for ribosome function and cell proliferation.

This study optimizes CRISPR-Cas13d for RNA targeting in zebrafish by improving gRNA design, nuclear targeting, and computational prediction, reducing collateral effects.

This study shows that the SOS1 inhibitor BI-3406 effectively reduces tumor growth in KRAS mutant cancers, similar to genetic SOS1 ablation, with comparable efficacy to another KRAS inhibitor.

This study identifies p38 MAPK inhibition as a neuroprotective strategy that synergizes with SMN upregulation to improve motor function and survival in SMA mice.

This paper introduces BLU-VIPR, an optogenetic CRISPR tool that enables precise spatiotemporal gene editing in T lymphocytes in vivo by regulating gRNA production with blue light.

This study identifies metabolic differences between proliferating and quiescent endothelial cells using proteomics and metabolomics, revealing distinct metabolic pathways in blood and lymphatic endothelium.

CoupleVAE predicts post-perturbation single-cell RNA-seq data by using coupled variational autoencoders, achieving better accuracy than existing models in three real datasets.

This study screens natural compounds to identify those affecting cell and chloroplast division in Chlamydomonas reinhardtii, finding that curcumin disrupts chloroplast division without affecting microtubule structures.

This study introduces a Sortase-based split-Cas9 system for precise genome editing, demonstrating its feasibility in E. coli and human cells with reduced off-target effects.