synaptic & neural circuits
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1,000+ papers
- NeurosciencebioRxivPreprint
Linking microscopic and mean-field descriptions ofdopaminergic modulation in neural circuits
Gabriele Casagrande, Augustinas Povilas Fedaravičius, Chloé Duprat…·Damien Depannemaecker
This study compares a dopamine-modulated mean-field model with its corresponding spiking network to evaluate the model's accuracy in capturing network dynamics.
- BioengineeringNature MethodsPeer-reviewed
A novel hybrid Wireless Integrated Sensing Detector for simultaneous EEG and MRI (WISDEM)
Yi Chen, Wei Qian, Daniel Razansky…·Chunqi Qian
This paper develops a wireless system for simultaneous EEG and fMRI recording, demonstrating its ability to capture neurovascular coupling in the somatosensory cortex.
- PhysiologybioRxivPreprint
Task Complexity and Limb Dominance Modulate the Effects of Ageing on Neuromuscular Function
Yuxiao Guo, Eleanor J. Jones, Abdulmajeed Altheyab…·Mathew Piasecki
This study examines how age and limb dominance affect neuromuscular function during tasks of varying complexity, finding asymmetric adaptations in older adults.
DOI 10.1101/2025.09.01.673460 - Animal Behavior & CognitionbioRxivPreprint
The Omniroute maze: a novel rodent navigation apparatus that integrates dynamically configurable routes, sensory cues and automated reward delivery
Adam W. Lester, Afsoon G. Mombeini, Manu Sasidharan Madhav
The paper introduces the Omniroute maze, a high-throughput rodent navigation system that automates route configuration, sensory cues, and reward delivery for behavioral experiments.
DOI 10.1101/2025.09.01.672969 - BioengineeringbioRxivPreprint
Human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry recapitulates opioid induced effects
Kevin J. Pollard, Frank Seipel, Nisha R. Iyer…·Michael John Moore
The paper develops a human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry that mimics opioid-induced effects through electrophysiological responses.
2 citations - PhysiologyFrontiers in Bioengineering and BiotechnologyPeer-reviewed
Effects of Single-Session Perturbation-Based Balance Training with Progressive Intensities on Resilience and Dynamic Gait Stability in Healthy Older Adults
Ringo Tang-Long Zhu, Friederike A. Schulte, Navrag B. Singh…·Deepak Kumar Ravi
This study examines the effects of a single session of perturbation-based balance training on balance recovery in older adults, finding improved stability but no change in recovery speed.
- Cell BiologybioRxivPreprint
Pathogenic mutations in Clathrin Heavy Chain associated with intellectual disability impair synaptic architecture and learning in Drosophila
Jyoti Das, Manisha Datta, Srikanth Pippadpally…·Deepa Subramanyam
DOI 10.1101/2025.08.28.672774 - Animal Behavior & CognitionbioRxivPreprint
Slower transitions between control states lead to reductions in cognitive flexibility over the lifespan
Ivan Grahek, Xiamin Leng, Alexander Fengler, Amitai Shenhav
This study shows that slower transitions between cognitive control states in older adults reduce cognitive flexibility, despite preserved ability to reach target states when given sufficient time.
DOI 10.1101/2025.08.27.672689 - BioengineeringCommunications ChemistryPeer-reviewed
Gene Conversion Directed Successive Engineering of Modular Polyketide Synthases
Wenzheng Jin, Jiaming Tu, Bei Zhang…·Yijun Chen
This paper describes a gene conversion-driven strategy to reprogram a modular PKS in the cinnamomycin biosynthetic gene cluster to generate a novel macrolide.
- PhysiologyCommunications BiologyPeer-reviewed
Functional MRI Signatures of Autonomic Physiology in Aging
Jiawen Fan, Meher R. Juttukonda, Sarah E. Goodale…·Jingyuan E. Chen
This study examines age-related changes in fMRI signatures of autonomic physiology, finding slower respiratory responses and faster cardiac responses with aging, with a notable turning point after age 60.
- BiophysicsbioRxivPreprint
Combined TIRF and 3D Super-Resolution Microscopy for Nanoscopic Spatiotemporal Characterization of Adhesion Molecules on Microvilli
Abdullah Alghamdi, Mansour M. Aldehaiman, Maged F. Serag…·Satoshi Habuchi
This paper develops a combined TIRF and 3D super-resolution microscopy platform to study the nanoscopic spatial organization of adhesion molecules on microvilli during cell rolling.
DOI 10.1101/2025.08.26.672391 - Bioengineeringnpj Systems Biology and ApplicationsPeer-reviewed
Leveraging agent-based models and deep reinforcement learning to predict taxis in cell migration: Insights from barotaxis
Daniel Camacho-Gómez, Raffaele Sentiero, Maurizio Ventre, José Manuel García‐Aznar
This paper develops a computational framework combining ABM and RL to predict barotactic cell migration using pressure gradients.
- Animal Behavior & CognitionbioRxivPreprint
Choice history biases evidence accumulation: a cross-species comparison from humans to mice
Kianté A. Fernandez, Alexander Fengler, Anne E Urai
The paper shows that mice, like humans, exhibit choice history bias in perceptual decision-making, using Diffusion Decision Models across species.
- Animal Behavior & CognitionJournal of NeurophysiologyPeer-reviewed
Eye and hand coarticulation during problem solving reveals hierarchically organized planning
Mattia Eluchans, Antonella Maselli, Gian Luca Lancia, Giovanni Pezzulo
This study examines how participants coordinate eye and hand movements during problem-solving tasks, revealing hierarchical planning strategies through coarticulation in gaze and cursor movements.
- PhysiologybioRxivPreprint
Mechanical energetic contributions of the rectus femoris during perturbed walking
Pawel R. Golyski, Gregory S. Sawicki
This study examines the mechanical role of the rectus femoris during perturbed walking, finding partial support for hypotheses about its lengthening and energetic demand reflection.
- BioengineeringbioRxivPreprint
High-throughput 3D super-resolution ultrasound imaging
Weisong Zhao, Nanchao Wang, Zhenqian Han…·Haoyu Li
This paper introduces FLAME, a high-throughput 3D ultrasound imaging technique that significantly improves resolution and speed for microvascular imaging in mouse organs.
- BioengineeringAdvanced Materials TechnologiesPeer-reviewed
Wirelessly-Powered Ingestible Electronic Capsule for Non-invasive Gastrointestinal Optogenetics
Mohamed Elsherif, Rawan Badr El‐Din, Zhansaya Makhambetova…·Khalil B. Ramadi
This paper develops an ingestible capsule for non-invasive optogenetic stimulation in rodents, demonstrating its functionality and safety in vivo.
5 citations - Animal Behavior & CognitionPLoS Computational BiologyPeer-reviewed
A feedforward mechanism for human-like contour integration
Fenil R. Doshi, Talia Konkle, George A. Alvarez
This paper shows that feedforward CNNs can mimic human contour integration without lateral connections, recurrence, or feedback by leveraging receptive field progression and contour bias.
- PhysiologybioRxivPreprint
Neural Correlates of Perceptual Grouping in Brain
Shefali Gupta, Tapan Kumar Gandhi
The paper investigates neural correlates of perceptual grouping using EEG, finding early cortical differences in responses to structured versus unstructured visual stimuli.
DOI 10.1101/2025.08.12.669980 - BioengineeringNeurorehabilitation and neural repairPeer-reviewed
Temporal Parameters Determine the Efficacy of Vagus Nerve Stimulation Directed Neural Plasticity
Juliet J. A. Addo, Connor Neifert, Tanya T. Danaphongse…·Seth A. Hays
This study investigates how temporal parameters of vagus nerve stimulation (VNS) affect neural plasticity, finding that moderate pulse frequencies enhance plasticity while burst patterns do not.
2 citations - BioengineeringFrontiers in Bioengineering and BiotechnologyPeer-reviewed
Personalization of Closed-Chain Shoulder Models Yields High Kinematic Accuracy for Multiple Motions
Claire V. Hammond, Heath B. Henninger, Benjamin Jon Fregly, Jonathan Adam Gustafson
This paper develops a personalized shoulder modeling framework that improves kinematic accuracy for multiple motions using closed-chain models with 5 DOFs.
- Animal Behavior & CognitionbioRxivPreprint
Thermotaxis behavior of Drosophila melanogaster: A quantitative analysis of sensory-motor integration and heat avoidance
Zeinab Moradi, Sara Jahedazad, Ehsan Hosseinian…·Ali Sadighi
This study quantifies Drosophila thermotaxis behavior using a thermal arena and machine learning, revealing distinct roles of peripheral and internal thermoreceptors in navigation.
DOI 10.1101/2025.08.11.668339 - BioengineeringbioRxivPreprint
Gender Differences in Lower Body Biomechanics: Insights from High-Resolution Motion Capture for Computer Vision and Assistive Technologies
DOI 10.1101/2025.08.10.669521 - BiophysicsbioRxivPreprint
Chaotic Dynamics and Effects of Cognitive State in Human Single Neurons
Saarth Anjali Chitale, Swetha Ravichandran
The paper identifies chaotic dynamics in human single neurons during memory tasks, showing increased chaos during cognitive engagement.
DOI 10.1101/2025.08.10.669543 - BiophysicsBiophysical JournalPeer-reviewed
Geometry effects on protein mobility in a synapse
Simon Dannenberg, Sofiia Reshetniak, Sarah Mohammadinejad…·Stefan Klumpp
This study uses in silico FRAP experiments to analyze how synaptic geometry and protein-vesicle binding affect protein mobility, identifying two key mechanisms influencing recovery times.
DOI 10.1016/j.bpj.2025.08.007 - BioengineeringJournal of BiomechanicsPeer-reviewed
Multiple, not single, recipient muscle tendon transfers produce well-directed thumb-tip forces in lateral pinch grasp: a simulation study with application to restoration of improved grasp after tetraplegia
Oliver Garcia, Joseph D. Towles
The paper uses simulation to show that multi-site tendon transfers can produce better-directed thumb-tip forces than single-site transfers for lateral pinch grasp in tetraplegia.
DOI 10.1016/j.jbiomech.2025.112882 - Animal Behavior & CognitionPRX LifePeer-reviewed
Experimental evidence of stress-induced critical state in schooling fish
Guozheng Lin, Ramón Escobedo, Xu Li…·Guy Theraulaz A
This study shows that schooling fish adjust their social interactions under stress to reach a critical state, enhancing adaptability, with group size influencing the need for external stressors.
8 citations - BioengineeringIEEE Transactions on Biomedical EngineeringPeer-reviewed
Passive Acoustic Dynamic Differentiation and Mapping: A Time-Domain Passive Cavitation Localization and Classification Approach
Nathan Caso, Krunal Patel, Tao Sun
This paper introduces PADAM, a time-domain passive cavitation imaging method that improves resolution and reduces artifacts compared to existing methods, enabling better cavitation monitoring and control in FUS therapy.
2 citations