Nanoparticle-Based Drug Delivery

This paper develops a modular LbL NP platform for targeting HSPCs and demonstrates its efficacy in both murine and human cells.

This study investigates the hemodynamic effects of PEGylated nanocomposites in rats, finding that complement activation and microvascular occlusion contribute to acute hypersensitivity reactions.

This paper develops a non-invasive method to deliver antibiotics to treat otitis media by using neutrophils to transport liposomes across the tympanic membrane.

This study shows that ApoE-tagged polymersomes retain more payload in injured nerves, while RVG-tagged polymersomes better penetrate nerves via intramuscular injection.

This study shows that the maturity of the endothelial glycocalyx affects how charged nanoparticles and polymers interact with endothelial cells, influencing toxicity and binding.

This study designs nanobody-targeted conditional antimicrobial therapeutics to deliver therapeutic cargos to bacterial infection sites by enhancing protease activation through proximity-enabled reactivity.

This paper develops platelet membrane-coated SPIONs for targeted Paclitaxel delivery and magnetic hyperthermia, showing enhanced tumor uptake and cytotoxicity.

This study compares DNA tetrahedron and exosome-based delivery of epirubicin in breast cancer cells, finding that DNA tetrahedrons enhance drug delivery and apoptosis more effectively than exosomes or free drug.

This study evaluates how nanoparticle size, shape, and surface charge affect their accumulation and penetration in 2D and 3D tumor models, finding that larger, negatively charged, and spherical NPs perform best.

This study develops stimuli-responsive protein vesicles using hydrophobic ion pairing to deliver proteins and siRNA, showing effective delivery and functional activity in cancer cell lines and organoid models.

This study shows that inhibiting the Hippo pathway component yes-associated protein increases nanoparticle internalization in cancer cells, independent of nanoparticle or cell properties.

This paper develops a nanoparticle drug delivery system targeting triple-negative breast cancer, showing reduced drug resistance and improved efficacy in vitro and in vivo.

This study investigates how VIP amphiphile micelle properties affect macrophage association, finding that VPAC targeting enhances binding while shape and size influence long-term association.

This study evaluates IO STMS nanocomposites in a zebrafish metastasis model, showing they inhibit metastatic outgrowth regardless of drug loading and improve embryo survival with increased HSA coating.

This paper develops a method to functionalize lipid nanoemulsions with antibodies for targeted cancer therapy using a cholesterol anchor and biotin-neutravidin coupling.

This paper develops dual-ligand micelles for targeted nanocarrier delivery in acute kidney injury, showing enhanced accumulation in injured kidneys and reduced off-target distribution.

This paper develops C-FLIPs, protease-activated liposomes that deliver macromolecular therapeutics to the cytosol of cancer cells, inducing tumor regression and immune memory.

This paper develops a chemical barcoding platform using halocodes to enable high-sensitivity detection and pooled screening of nanoparticles, demonstrating its utility in quantifying delivery and spatial mapping.

This paper develops PA17, a toxin-derived ligand targeting TEM8 in melanoma, which enhances nanoparticle-mediated drug delivery and reduces tumor mass effectively.

This paper develops a computational model to simulate nanoparticle drug delivery in virtual arterial geometries, showing that circadian rhythm modulated blood flow and vessel geometry affect drug adhesion and retention.

This paper uses machine learning to predict critical quality attributes and process parameters for microfluidic liposome production, improving understanding of lipid behavior and streamlining drug delivery system development.

This study investigates how tissue-specific ECM properties affect nanoparticle diffusion and cellular uptake, finding that PEGylation strategy impacts ECM penetration and uptake differently across tissues.

This study shows that gefitinib enhances endocytosis of EGFR-targeting conjugates, improving ADC toxicity in glioblastoma cells.

This study demonstrates that the caveolae pumping system in lung endothelial cells can rapidly and specifically deliver nanoparticles to the lungs, outperforming passive delivery and RES scavenging.

This study shows that alternating current can enhance drug delivery and overcome resistance in brain tumors by modulating intracellular trafficking.

This paper develops peptide-coated nanocapsules for targeted drug delivery to pancreatic β-cells, showing effective in vitro and in vivo targeting and cargo delivery.

This paper introduces a novel method for creating stable aqueous nanoparticles from pure conjugated molecules, demonstrating their efficacy in treating various diseases in vivo.

This study evaluates how protein coronas from cerebrospinal fluid affect nanoparticle interactions with brain cells, finding that CSF-derived coronas enhance these interactions.

This paper demonstrates the use of magnetic spherical nucleic acids to remotely control cell-free protein synthesis in tissue phantoms using magnetic hyperthermia.

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.