Gut microbiota and health

This paper introduces a generative model based on the consumer/resource framework to design host-associated microbiomes that correspond to desired host phenotypes and vice versa.

This study shows that lifetime exposure to different chow diets significantly affects mouse phenotypes and gut microbiota, while developmental exposure reduces variability.

The paper investigates how host genetics shape microbiome composition across generations, finding that host genotype has a stronger influence than maternal legacy after the first generation.

This study examines how Atg16l1 deletion in intestinal epithelial cells affects fecal microbiota shifts during pregnancy in mice, identifying altered microbial composition and functional potential.

The paper examines how host subspecies divergence, hybridisation, and spatial environment influence microbiome composition in house mice, finding that host genetics shape microbiome similarity more than hybridisation.

This study shows that dietary fibers shape gut microbial communities differently in lean and obese individuals, affecting metabolite production based on initial microbial composition.

This study shows that Bacteroides thetaiotaomicron enhances H2S production in Bilophila wadsworthia through sulfate provision, altering microbial metabolism and potentially contributing to gut inflammation.

This study shows that gut environmental factors explain more variation in microbiome and metabolome than diet or personal traits in healthy adults.

This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.

The paper introduces a Bayesian zero-inflated negative binomial regression model to analyze microbiome data in children cohorts, revealing insights into microbial abundance and covariate effects.

This study identifies putative keystone taxa in the human gut microbiome using correlation network analysis and evaluates the impact of taxonomic resolution on their detection.

This paper investigates how acarbose affects two Bacteroides species, showing that Bt growth is inhibited while Bo growth is not, revealing complex mechanisms involving Sus system interactions and differential gene expression.

The paper develops a computational pipeline to classify gut microbiome states using functional annotations, showing comparable performance to microbial profiles and identifying reliable discriminant variables.

This study shows that bacterial infection induces intercrypt goblet cells (icGCs) in mice, which produce a protective mucus layer with unique glycosylation that blocks pathogens.

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.

This study investigates how orange carrot carotenoids affect the colonic proteome in obese mice, finding increased mucus production and barrier proteins.

This study examines how lambda-cyhalothrin affects gut microbiota and bile acid metabolism in mice, finding increased bile acids and shifts in microbial families.

This study compares gut microbiota assembly patterns in lab and wild mice, finding conserved age-related diversity and abundance trends despite taxonomic differences.

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.

The paper describes a prospective cohort study to assess gut microbiota development and associated factors in infants during the first two years of life in Pakistan.

This study shows Giardia reduces the beneficial effects of Lactobacillus in malnourished mice, altering microbial balance and increasing intestinal damage.

This study shows that Trichinella spiralis infection protects against colitis in mice by altering the gut microbiota, increasing SCFA-producing bacteria, and enhancing goblet cell differentiation and IL-10 levels.

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

This study shows that zebrafish gut microbiome influences protein absorption by altering lysosome-rich enterocytes' expression of digestion machinery and microbial interactions.

This study compares gut and oral microbiota in women with breast cancer, ductal carcinoma in situ, and healthy controls, finding significant gut microbiota differences but not oral ones.

The paper isolates and compares 63 Segatella copri strains from a single gut microbiome, revealing phenotypic and host-microbe interaction differences.

This study compares the effects of grain-based diets and purified diets with varying fiber content on gut morphology and microbial communities in mice.

The paper identifies changes in oral and gut microbiome virulence and antimicrobial resistance genes associated with increasing severity of chronic liver disease.

This study evaluates intra-individual variability in gut health markers over time and shows that optimized sample processing reduces analytical variability.