Neuroscience and Neuropharmacology Research

The paper investigates synaptic properties of connections between pyramidal neurons and basket cells in the mouse prefrontal cortex, revealing differences in excitatory and inhibitory currents and mutual connectivity between basket cell types.

This study shows that clustering of glycine receptors enhances their ion affinity through electrostatic effects, offering insights into ion channel function and drug development.

The paper investigates how Mu and Delta opioid receptors modulate inhibitory transmission in the prefrontal cortex through distinct cellular and molecular mechanisms in mice.

This paper introduces ORCHID, an all-optical method to measure inhibitory receptor driving forces, demonstrating its accuracy and application in neurons and astrocytes.

The paper investigates how prolonged hyperactivity in hippocampal neurons leads to persistent chloride ion accumulation in a subset of cells using imaging and statistical analysis.

The paper shows that repeated winning in male mice leads to three stages of plasticity in the VMHvl aggression circuit, enhancing generalized aggression.

This study introduces Opto2B, a tool to selectively modulate GluN2B diheteromers, revealing their minor role in synaptic and extrasynaptic NMDAR pools in adult hippocampal CA1 pyramidal cells.

This study identifies a bidirectional allosteric pathway between the extracellular and transmembrane domains of NMDA receptors, revealing how conformational changes in one domain influence the other.

The paper maps long-range axonal projections of genetically defined neuron classes in mouse somatosensory cortices using light-sheet imaging and identifies distinct innervation patterns.

The paper develops an in vitro system to study synaptic engrams by synchronizing neuronal firing patterns and observing synapse strengthening.

The paper shows that inhibitory input to pyramidal neurons in layer 2/3 depends on their embryonic progenitor type, shaping local inhibitory subnetworks.

The paper develops a nanobody-based PLA to detect and quantify native Arc/Arg3.1 oligomers in hippocampal neurons, revealing constitutive and stimulus-regulated complexes.

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

This study uses an alkaline phosphatase immunolabeling method to characterize FLT3 and other neuronal proteins in brain tissue, revealing neuron-specific FLT3 expression patterns in mouse and human cerebellum.

This study shows that deletion of the proton-activated chloride channel in neurons leads to endosomal hyper-acidification, impairing AMPA receptor endocytosis and long-term depression.

This study investigates the role of group I mGluRs in synaptic tagging and capture (STC) in mouse hippocampus, showing their requirement for heterosynaptic priming of long-term potentiation.

This study shows chronic fluoxetine reduces mitochondrial activity in parvalbumin interneurons of the prefrontal cortex, potentially leading to disinhibition and enhanced synaptic plasticity.

The paper proposes a negative-feedback theory for memory maintenance through KIBRA-PKMζ interactions and validates it with two models showing bistability in synaptic states.

The paper shows that Hebbian induction in neonatal hippocampal synapses creates a labile potentiation by adding an AMPA-labile signaling unit, distinct from standard LTP or STP.

This study investigates the developmental program and functional properties of axon-carrying-dendrite neurons, revealing unique features of their axon initial segment.

The paper compares NMDA receptor decay kinetics in lamina I pain neurons across sex and species, finding conserved heterogeneity but species-specific differences in subunit contributions.

The paper characterizes a VGLUT1 knock-down mouse model and finds that reduced VGLUT1 expression does not significantly affect quantal size or frequency of glutamate release.

This study identifies adrenergic signaling as a gatekeeper for astrocyte responses to neurotransmitters, showing its role in regulating neuronal activity and behavior in both Drosophila and mammals.

MN12 treatment increases PKMζ expression, restoring LTP and spatial learning in mice with closed head injury.

This study shows that nucleus accumbens astrocytes can increase or decrease social behavior in rats through manipulations of their signaling.

This study identifies miR153 as a regulator of gephyrin translation during inhibitory long-term potentiation, showing its downregulation enables synaptic strengthening.

This study shows that short metabolic failures cause lasting increases in glutamate release, while longer episodes lead to postsynaptic transmission failure in hippocampal neurons.

This study shows that maternal immune activation disrupts the excitation-inhibition balance in CA1 pyramidal neurons, leading to altered spike timing and behavioral abnormalities in offspring.

This study investigates how Neuroligin-2 interacts with MDGA1 and MDGA2 to regulate gephyrin aggregation and GABAAR function in mouse hippocampal synapses, revealing MDGA1's role in modulating these processes.