Vasanthi Jayaraman

The paper identifies dopamine as a direct agonist of GluDs, showing G-protein regulation of their activity and implications for neurological diseases.

This study uses simulations and assays to show Rheb switches between membrane orientations, affecting mTORC1 activity.

This study shows memantine inhibits calcium-permeable AMPA receptors, revealing a new mechanism distinct from NMDA receptors and suggesting therapeutic potential for neurological disorders.

This study shows that glutamate gating of AMPA receptors is temperature sensitive and distinct from PAM-induced gating, revealing conserved structural motifs and desensitization mechanisms.

The paper identifies AD-associated changes in m6A methylation on promoter antisense RNAs and shows their role in regulating gene expression and neuronal survival in Alzheimer's disease.

This study identifies a bidirectional allosteric pathway between the extracellular and transmembrane domains of NMDA receptors, revealing how conformational changes in one domain influence the other.

This study reveals how negative allosteric modulators inhibit AMPA receptors by disrupting glutamate binding and outcompeting positive modulators, offering insights for therapeutic design.