Parkinson's Disease Mechanisms and Treatments

This study examines aperiodic EEG activity in Parkinson's disease during cognitive tasks, finding increased offsets and task-related differences but no behavioral or clinical correlations.

This paper conducts a multi-ancestry genome-wide meta-analysis of Parkinson's disease, identifying 78 independent loci and 23 genes associated with PD risk.

The paper examines gene expression changes in microglia from LRRK2-WT and G2019S knock-in mice treated with zymosan and MLi-2, identifying differential expression patterns and potential PD-related pathways.

This study shows that the VPS35[D620N] mutation causes lysosomal dysfunction, activates LRRK2, and promotes the lysosomal association of RILPL1 and TMEM55B through phosphorylation of Rab proteins.

The paper investigates the sex-dimorphic neuroprotective role of CD163 in a Parkinson's disease mouse model using CD163 knockout mice.

This paper develops all-D-peptide ligands that disassemble alpha-syn preformed fibrils into monomers, showing potential for treating Parkinson's disease.

The paper shows that gut mucosal cells can transfer alpha-synuclein to the vagus nerve, suggesting a non-neuronal source of fibrillar alpha-synuclein in Parkinson's disease.

The paper develops and validates an expanded antibody panel to capture diverse alpha-synuclein conformations and modifications in Lewy body diseases.

This study identifies dAux's role in regulating lysosomal V-ATPase assembly through phosphorylation, which is critical for α-synuclein degradation in glia and PD progression.

This study shows that ablation of the Rcc1l gene in dopaminergic neurons leads to Parkinsonian-like symptoms and neurodegeneration in mice.

This study shows that phosphorylation of α-synuclein at Serine-129 is a physiologic trigger for protein interactions and synaptic function, challenging its previous association with pathology.

This study shows that blocking kappa opioid receptors increases the rate of L-DOPA-induced dyskinesia development in a rat Parkinson's model but does not affect motor symptoms or tonic dopamine levels.

This study identifies genetic risk factors for early-onset Parkinson's Disease in a South Asian population, finding a genome-wide significant signal in the SNCA region and associations with BSN gene variants.

This study identifies LRP10 interactors and pathways, showing its role in autophagy and NDFIP1-mediated alpha-synuclein secretion, with differences between LRP10-WT and LRP10-Splice variants.

This study identifies biotin pathway dysregulation as a key mechanism linking manganese toxicity to Parkinson's disease using Drosophila and human iPSC models, showing biotin supplementation rescues neurotoxic phenotypes.

The paper investigates respiration changes in a rat Parkinson disease model across different behavioral states, finding increased respiratory frequency and amplitude during quiet waking but not sleep.

This study characterizes early-stage behavioral, neuronal, and ultrastructural changes in a graded-dose 6-OHDA mouse model of Parkinson's disease, showing dose-dependent motor deficits and dopaminergic neuron loss.

The paper examines resting EEG activity in Parkinson's Disease patients on and off medication, finding medication-invariant differences in aperiodic activity that contribute to neural correlates of the disorder.

This study identifies up-regulation of human endogenous retrovirus (HERV) transcripts in Parkinson's disease (PD) across multiple tissues and blood, linking TE activation to PD pathogenesis and potential treatment monitoring.

This study identifies differential activation states of D1-MSN subpopulations in response to L-DOPA treatment and links these changes to LID development through activin/TGFβ signaling.

Intronic GBA1 variant rs3115534-G, common in African and African admixed ancestry but rare elsewhere, raises Parkinson's disease risk (OR 1.58) and lowers onset age.

This study shows that LRRK2 does not significantly affect the formation of α-synuclein inclusions in the forebrain of mice after PFF injection, but may influence microglial activation.

This paper introduces midbrain-striatum assembloids with inducible aging to model early Parkinson's disease phenotypes and nigrostriatal connectivity.

This study introduces a G51D mutation in the rat Snca gene, leading to synaptic mislocalization of α-synuclein and increased susceptibility to Lewy-like pathology.

This study evaluates Gardenin A's effects on A53T-α-syn mice, showing improvements in cognitive and motor function and reductions in pathological markers.

This study identifies fibrinogen and complement factor H as potential biomarkers for Parkinson's disease with cognitive impairment by showing they induce motor and cognitive deficits in mice.

This study shows that C1q-dependent engulfment of alpha-synuclein by ENS macrophages leads to their exhaustion and worsens Parkinson's-like gut pathology.

This study examines neuromelanin accumulation and dissipation in the locus coeruleus across aging, finding increased intensity until age 60 followed by a decline, with cognitive associations in older adults.

The paper investigates the role of Cav1.2 Ca2+ channels in pacemaking of PPN cholinergic neurons and their link to oxidative stress and Parkinson's disease vulnerability.