Parkinson's Disease Mechanisms and Treatments

This study models aSyn assemblies in living cells and shows that Sph1-aSyn interactions influence inclusion formation, morphology, and localization, providing insights into protein aggregation and potential therapeutic strategies.

This study shows that LRRK2 kinase inhibition reverses tau pathology progression in mice with the G2019S mutation but not in wildtype mice.

The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.

The paper tests a G2019S selective LRRK2 inhibitor, EB-42168, showing it reduces mtDNA damage in G2019S models and patient cells better than a non-selective inhibitor.

The paper investigates how familial Parkinson's disease mutations affect pre-mRNA splicing in dopaminergic neurons, identifying five functional classes of splicing changes and potential biomarkers and therapeutic targets.

This study shows that the LRRK2 G2019S mutation impairs Th9 and Treg cell differentiation while enhancing Th2 differentiation through JAK/STAT3 signaling in T cells.

This study shows GLP-1R agonism improves Parkinson's disease by restoring neuronal insulin signaling and reducing glial inflammation, with clinical benefits in patients with higher baseline MAPK expression.

This study shows that mitochondrial antigen-specific CD8+ T cells can induce nigrostriatal dysfunction and dopamine neuron degeneration in mice, supporting an immune-driven mechanism in Parkinson's disease.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

The paper develops a deep learning framework to diagnose Parkinson's disease in Drosophila by analyzing kinematic features from behavioral data.

The paper shows that Park7 deletion causes sex-specific transcriptome changes in male mouse midbrain astrocytes via the NRF2-CYP1B1 axis, affecting oxidative stress and EMT processes.

The paper investigates the association between the non-coding GBA1 rs3115534 variant and REM sleep behavior disorder in Nigerians with Parkinson's disease.

The paper links excessive cortical beta oscillations to slow-wave sleep dysfunction in mild parkinsonism using a nonhuman primate model.

This study shows that LC injury modifies neuroinflammation in the ventral midbrain during DSS-induced colitis, highlighting the neuroprotective role of the locus coeruleus.

The paper shows that tocilizumab, an IL-6 receptor inhibitor, prevents astrocyte-induced neurotoxicity in Parkinson's disease by blocking IL-6 signaling in neurons.

This study investigates decision-making impairments in Parkinson's disease patients with apathy using reinforcement learning tasks and fMRI, finding reduced value-based choices and distinct neural activation patterns.

This study shows that Rab8a and Rab10 deficiencies cause distinct lysosomal and Golgi defects in human neurons, with opposing effects on lysosomal pH and proteostasis of α-synuclein and tau.

This study identifies a gene regulatory pathway involving SATB1, MIR22HG, and GBA that leads to glucocerebroside accumulation and cellular senescence in dopaminergic neurons, contributing to Parkinson's Disease and aging.

This study replicates findings from Hanganu et al. (2014) on Parkinson's disease neuroimaging biomarkers using PPMI data, finding partial replication of cortical thinning and cognitive decline associations.

This study uses single-cell immunoprofiling to identify distinct immune signatures in Lewy body disease compared to other neurodegenerative and immune conditions.

This study identifies electrophysiological signatures of anxiety in Parkinson's disease using resting-state EEG, showing altered power and connectivity patterns associated with clinical anxiety scores.

The paper analyzes single-cell transcriptomics data from Parkinson's Disease patients and controls to identify cell type-specific molecular responses and pathways involved in neurodegeneration.

The paper investigates PINK1's interaction with nucleotides and kinetin, revealing structural changes and binding constraints that affect its activity and mitophagy.

This study investigates redox homeostasis in the gastrointestinal tract of a brain-first Parkinson's disease rat model and finds no significant redox dyshomeostasis.

This study shows that impaired lysosomal proteolysis in astrocytes leads to proteostasis failure in midbrain neurons in an early-onset PD model.

The paper quantifies regional synaptic degeneration in Parkinson's Disease and Dementia with Lewy bodies, linking it to alpha-synuclein burden, axonal damage, and clinical outcomes.

The paper investigates acetylated alpha-Tubulin redistribution in Parkinson's disease brains and links it to alpha-Synuclein pathology and Lewy body formation.

This study examines how Alzheimer's disease pathology in dementia with Lewy bodies correlates with astroglial α-synucleinopathy and regional differences in pathology load and morphology.

This study examines cerebellar activity in PINK1 knockout rats during gait, finding hypoactivity in specific frequency bands linked to potential compensatory mechanisms for gait deficits.

The paper shows that morphological changes in dopaminergic neurons of C. elegans correlate with functional impairments, as worms with dendrite degeneration paralyze more in dopamine solutions.