Alzheimer's disease research and treatments

This study uses deep learning to integrate proteomics and PPI data, identifying astrocytes and GPNMB+ microglia as novel moderators of Aβ-tau interaction in early Alzheimer's disease.

The paper examines how Alzheimer's pathology affects PV interneurons and excitatory neurons in different brain regions of hAPP-KI mice, finding regional differences in neuronal excitability.

This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.

This paper uses isotope-edited FTIR spectroscopy to reveal distinct molecular structures of A{beta}42 oligomers, showing differences in residue positioning and interactions between detergent-stabilized and non-detergent-stabilized forms.

The paper investigates the connection between Aβ and tau proteostasis networks, identifying HSP90 as a central hub that links their dysregulation in Alzheimer's disease.

The paper shows that GVB-positive neurons are protected against tau-induced protein synthesis impairment and neurodegeneration.

This study shows that homeostatic activation of 26S proteasomes by PKA protects against brain and cardiac dysfunction in Alzheimer's disease mice.

This study models how amyloid beta pores disrupt synaptic function by altering calcium dynamics and interacting with ER dysfunction, revealing temporal patterns of synaptic hyperactivation and hypoactivation.

This study shows HSV-1 infection alters MAPT splicing, increases 4R-Tau protein and hyperphosphorylation, and promotes Tau pathology in neural models.

This study analyzes lifespan differences between male and female Alzheimer's disease mouse models, finding significant sex-based survival variations in two AD models.

The paper uses long-read sequencing to identify and characterize APOE haplotypes in a Spanish cohort, finding associations between specific haplotypes and reduced risk of Alzheimer's disease progression.

This study shows that Ser14-phosphorylated Rpn6 protects against tauopathy-related brain and heart pathology by maintaining proteostasis.

This study examines electrophysiological changes in locus coeruleus neurons of aged P301S mice, finding reduced excitatory inputs and neuronal activity linked to tau pathology.

This paper uses peptidomimetic foldamers to study tau misfolding by inducing specific conformations of PHF6 and PHF6* sequences, showing that extended conformations drive aggregation while β-hairpins prevent it.

This study shows that MAIT cell deficiency worsens tau pathology and hippocampal atrophy in P301S tau transgenic mice by increasing neuroinflammation and compromising meningeal barrier integrity.

This study shows that reducing Asrij levels in an Alzheimer's disease mouse model decreases microglial inflammation and Aβ pathology, improving cognitive and neuronal outcomes.

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.

The paper shows that a synonymous variant in PILRA decreases mRNA and protein levels by disrupting a ramp sequence, providing a biological mechanism for its association with Alzheimer's disease.

The paper develops a FRET-based sensor using engineered fluorescent proteins to quantitatively detect amyloid fibrils, validated with PAPf39 fibrils.

This study uses mathematical models to analyze amyloid and tau interactions in Alzheimer's Disease, finding that a one-way amyloid-to-tau aggregation model best explains their spatiotemporal progression.

This study shows that intranasal lithium salt delivery in RFV reduces brain inflammation and pyroptosis, improves memory and depression-like behaviors in 5XFAD mice, with minimal side effects.

This study identifies genetic covariance between early-onset Alzheimer's disease and lipid traits, highlighting three novel loci and potential causative genes.

This study shows that genetic risk variants in endolysosomal network genes correlate with endolysosomal dysfunction in neural cells in Alzheimer's disease.

This study compares Metformin and Semaglutide for Alzheimer's risk reduction in Type II Diabetes using network pharmacology, MR, and transcriptomics, finding Metformin more effective through dual mechanisms.

This study shows that perimenopause increases Aβ aggregation and glial activation in specific hippocampal regions in female 5xFAD mice, but not cognitive deficits.

This paper introduces ProPPr, a method for proteomic profiling of phospho-tau aggregates in tauopathies, revealing common and disease-specific proteins associated with these lesions.

This study shows that APP overexpression and Aβ exposure affect neural activity differently in immature and mature cultures, suggesting distinct roles in Alzheimer's disease mechanisms.

This paper develops A{beta}-sensitive synthetic Notch receptors for engineered astrocytes to target amyloid-{beta} in Alzheimer's disease and modulate the neurodegenerative niche.

This study examines the effects of a single rapamycin dose on brain glucose metabolism and synaptic density in rats using PET imaging, finding increased metabolism and decreased synaptic density.

This study identifies novel Cdk5 inhibitors that improve T2D symptoms and cognitive function in a mouse model.