Epilepsy research and treatment

This paper systematically reviews chemically-induced seizure models in zebrafish, identifying common chemoconvulsants and highlighting variability in protocols and reporting practices.

This study investigates the association between rare non-coding deleterious variants and epilepsy, finding a significant link with genetic generalized epilepsy (GGE) but not with non-acquired focal epilepsy (NAFE).

This study examines how sex and gonadectomy affect seizure susceptibility and mortality in mice using a repeated low-dose kainic acid injection model.

This study evaluates on-demand low-frequency stimulation for seizure control in a mouse model of mesial temporal lobe epilepsy, showing improved efficacy and no cognitive deficits.

This study evaluates spontaneous recurrent seizures in rats after status epilepticus induced by organophosphate agents, finding hippocampal neuronal loss and mossy fiber sprouting associated with chronic epilepsy.

The paper investigates inhibitory deficits in the hippocampal CA2 region of a mouse model of temporal lobe epilepsy, identifying reduced cholecystokinin-expressing interneurons and impaired inhibition.

This study uses cell-type deconvolution and single-cell signatures to analyze bulk RNA-seq data from FCD patients, revealing subtype-specific cellular changes, including astrogliosis in FCD IIb.

This paper describes a novel mouse model of SLC6A1 mutation-associated neurodevelopmental epilepsy, showing seizure burden correlates with behavioral deficits and drug responses.

This paper evaluates an artificial bridge that restores hippocampal loop function in an in vitro model of limbic seizures, reducing ictal activity and restoring connectivity.

This study investigates SCN1A mutations in excitatory neuronal networks derived from patient hiPSCs, revealing mutation-specific phenotypes that correlate with clinical outcomes and drug responses.

This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.

This study shows that Sema4D treatment reduces seizure susceptibility and restores benzodiazepine sensitivity in a mouse model of Status Epilepticus.

This paper optimizes a neurostimulation protocol to desynchronize pathological neuronal firing patterns during and after epileptic seizures using a computational model.

The paper investigates the relationship between sleep spindles and treatment response in epileptic encephalopathy, finding that increased spindles correlate with cognitive improvement after diazepam treatment.

This study demonstrates that gene therapy targeting GluK2 reduces seizures in TLE models and patient-derived slices.

This study shows that in mice, female-specific left-right asymmetry in hippocampal function interacts with estrous cycle stage to influence chronic seizure patterns following kainic acid injection.

This study uses multisite thalamic recordings to show that seizure propagation in TLE involves thalamic regions beyond the ANT, with pulvinar involvement being more prominent in 60% of patients.

This paper introduces a novel Dravet syndrome mouse model with a Scn1a R613X nonsense mutation, showing seizures, premature death, and hyperactivity.

This study characterizes and automatically quantifies seizure-related behaviors in Xenopus laevis tadpoles using chemical induction and video analysis software.

This paper develops a high-throughput screening system for analyzing calcium waveform features in neurons to characterize anti-epileptic drugs and predict their mechanisms of action.

This study identifies TRPM4 as a contributor to mossy cell death in temporal lobe epilepsy following status epilepticus, affecting seizure susceptibility and memory deficits.

The paper identifies cell loss and subtype-specific vulnerability of interneurons in the subiculum of a mouse model for mesial temporal lobe epilepsy.

This study shows that blocking postictal hypoxia prevents SUDEP in mice by preventing seizure-induced vasoconstriction.

This study examines the acute effects of antiseizure drugs on background neuronal oscillations in a Dravet syndrome mouse model, finding that some drugs reduce interictal spikes and alter frequency bands while others do not.

This study shows sodium selenate reduces seizures, cognitive dysfunction, and sensorimotor deficits in a rat model of chronic drug-resistant temporal lobe epilepsy.

This study identifies atypical intrinsic neural timescales in temporal lobe epilepsy, showing reduced timescales in multiple brain regions and high accuracy in classifying patients and lateralizing seizure foci.

The paper investigates the role of prefrontal parvalbumin interneurons in attention and links their dysfunction to attentional impairments in a mouse model of absence epilepsy.

This study investigates how higher-order thalamic nuclei contribute to the spread and maintenance of spike-and-wave discharges in absence seizures using GAERS models.

This study investigates how early suppression of neuronal excitability in a rat model of subcortical band heterotopia affects epileptogenesis and seizure progression.

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.