Influenza Virus Research Studies

This paper demonstrates that Triton-X 100-treated virus-based ELLA overcomes HA interference in IBV, revealing discordant antigenic evolution between HA and NA.

This study investigates the effects of oral exposure to pasteurized HPAI H5N1 virus in milk on immune response and mortality in mice, finding limited health risk and no prevention of immune-mediated protection.

This study reviews laboratory studies on avian influenza virus infection in wild North American birds to assess susceptibility and transmission parameters.

The paper investigates the delayed incursion of H5N1 avian influenza in Antarctica by analyzing surveillance data from before confirmed cases.

The paper documents reduced seabird and sea duck mortalities in eastern Canada during the 2023 breeding season compared to 2022 following HPAI introduction, with more diverse species affected in 2023.

This study investigates H5N1 clade 2.3.4.4b virus infection in calves and lactating cows, finding that mammary gland infection causes severe mastitis and reduced milk production, with transmission likely via milk rather than respiratory routes.

This study develops a high-throughput sequencing-based neutralization assay to measure antibody titers against multiple influenza strains and finds that vaccination effects vary by individual and prior vaccination history.

This study develops an intranasal influenza vaccine using spike nanobicelles that elicit pan-H1 antibodies and provide protection against diverse H1N1 viruses.

This study shows that heterologous immunization primes antigen-specific memory CD4 T cells, enhancing early germinal center response but not antibody generation in influenza infection.

The paper identifies a single ANP32 locus in ticks that generates multiple variants supporting Thogoto virus polymerase activity, showing evolutionary plasticity across species.

This study shows that H5N1 avian influenza virus remains stable in lactose for 14 days under refrigeration but is inactivated by heat or citric acid.

This study shows that influenza A virus uses actomyosin motility for vRNP packaging by blocking myosin activity and observing disrupted vRNP aggregation.

This study models the antigenic evolution of seasonal influenza viruses using PREDAC and finds no need to update vaccine strains for the 2025 season.

The paper estimates the time of introduction and contact rates of HPAI H5N1 in U.S. poultry flocks using mathematical modeling and mortality data.

This study shows H7 influenza A viruses lose Neu5Gc binding during adaptation to chickens, enhancing transmissibility in poultry but reducing transmission back to wild birds.

This study detects H5N1 HPAIV in Antarctic and sub-Antarctic regions, identifies affected species, and traces the virus's origin and potential spread.

This study identifies Fc-dependent protective antibodies against influenza A virus neuraminidase, showing that epitope availability and Fc-mediated effector functions influence their efficacy.

The paper estimates 40,966 wild bird mortalities in eastern Canada due to H5N1 avian influenza in 2022, highlighting potential population-level impacts on Northern Gannets and American Common Eiders.

The paper uses citizen science data to identify wild bird species associated with HPAIV outbreaks in poultry, showing the value of such data for rapid disease surveillance.

This study assesses the seroprevalence of influenza A and B viruses in goats and sheep, finding high antibody rates against avian H5, H7, and H9 subtypes, suggesting these animals may be novel hosts for pandemic influenza viruses.

This study examines the morphological changes and cytokine response of chicken bone-marrow derived dendritic cells infected with high and low pathogenic avian influenza viruses.

This study shows that pre-existing antibodies inhibit de novo B cell responses to influenza antigens in mice, but not to other vaccine antigens.

This paper develops a single-component self-assembling nanoparticle vaccine targeting conserved M2e domains from both influenza A and B viruses, showing 100% protection against H1N1 and 70% against Yamagata lineage influenza B in mice.

This study compares macrophage and monocyte responses in young and adult mice during influenza infection, finding divergent mechanisms of lung pathology.

The paper identifies a new influenza A subtype H18N12 in bats from Colombia, based on genetic analysis of viral sequences and phylogenetic studies.

This study identifies the expression of avian and human influenza A virus receptors in bovine mammary glands, suggesting cattle could act as a mixing vessel for novel IAV generation.

This study identifies enhanced diversifying selection on polymerase genes in H5N1 clade 2.3.4.4b viruses, linking it to expanded host range and increased pathogenicity.

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.